Nascimento Laís Silva, Marson Fernando Augusto Lima, Dos Santos Raquel de Cássia
Laboratory of Natural Products, São Francisco University, Bragança Paulista, Brazil.
Laboratory of Molecular Biology and Genetics, São Francisco University, Bragança Paulista, Brazil.
Front Med (Lausanne). 2024 Oct 23;11:1440101. doi: 10.3389/fmed.2024.1440101. eCollection 2024.
The novel coronavirus-induced severe acute respiratory syndrome (COVID-19) led to one of the most significant global pandemics of the 21st century, causing substantial challenges for healthcare systems worldwide, including those in Brazil. This study aimed to investigate the demographic and clinical profiles of hospitalized patients in Brazil who had both COVID-19 and Crohn's disease (CD) over a 2-year period.
An epidemiological analysis was conducted using data from Open-Data-SUS. The study focused on describing the demographic characteristics, clinical manifestations, comorbidities, and hospitalization details of patients afflicted with severe acute respiratory syndrome due to COVID-19 and CD, with the aim of predicting mortality risk.
The states of São Paulo, Paraná, and Minas Gerais accounted for 50% of the reported COVID-19 cases. The most affected racial group consisted of individuals who self-declared as mixed race. Common comorbidities included heart disease, diabetes mellitus, and obesity. The age group most affected was 25 to 60 years old, particularly among hospitalized patients with both CD and COVID-19 who ultimately succumbed to the illness. A multivariable analysis was conducted to identify the following significant risk factors for death: (a) the presence of neurological disorder (OR = 6.716; 95% CI = 1.954-23.078), (b) the need for intensive care (OR = 3.348; 95% CI = 1.770-6.335), and (c) the need for invasive mechanical ventilation (OR = 59.017; 95% CI = 19.796-175.944).
There was no discernible gender-based prevalence among hospitalized patients with CD and COVID-19; however, individuals of mixed race were disproportionately affected. The 25 to 60 age group emerged as the most vulnerable demographic group, with high risks of hospitalization and mortality. Moreover, the study highlights the potential for COVID-19 to induce systemic pathologies that may result in long-term degenerative effects and sequelae.
新型冠状病毒引发的严重急性呼吸综合征（COVID-19）导致了21世纪最重大的全球大流行之一，给包括巴西在内的全球医疗系统带来了巨大挑战。本研究旨在调查巴西在两年期间同时患有COVID-19和克罗恩病（CD）的住院患者的人口统计学和临床特征。
利用开放数据SUS的数据进行了一项流行病学分析。该研究专注于描述因COVID-19和CD导致严重急性呼吸综合征患者的人口统计学特征、临床表现、合并症和住院细节，目的是预测死亡风险。
圣保罗州、巴拉那州和米纳斯吉拉斯州占报告的COVID-19病例的50%。受影响最严重的种族群体是自我认定为混血的个体。常见的合并症包括心脏病、糖尿病和肥胖症。受影响最严重的年龄组为25至60岁，特别是在最终死于该疾病的同时患有CD和COVID-19的住院患者中。进行了多变量分析以确定以下死亡的重要危险因素：（a）存在神经系统疾病（OR = 6.716；95% CI = 1.954 - 23.078），（b）需要重症监护（OR = 3.348；95% CI = 1.770 - 6.335），以及（c）需要有创机械通气（OR = 59.017；95% CI = 19.796 - 175.944）。
在同时患有CD和COVID-19的住院患者中，没有明显的基于性别的患病率差异；然而，混血个体受到的影响不成比例。25至60岁年龄组成为最脆弱的人口群体，住院和死亡风险高。此外，该研究强调了COVID-19诱发可能导致长期退行性影响和后遗症的全身病理状况的可能性。
