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根治性膀胱切除术患者中性粒细胞与淋巴细胞比值的预后价值：一项系统评价和荟萃分析

Prognostic value of neutrophil to lymphocyte ratio for patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis.

作者信息

Chen Zhan, Zhang Yao, Chen Telei

机构信息

Department of Urology, Cixilntegrated Traditional Chinese and Western Medicine Medical, Ningbo, Zhejiang, China.

Department of Urology, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, China.

出版信息

Front Oncol. 2024 Oct 24;14:1463173. doi: 10.3389/fonc.2024.1463173. eCollection 2024.

DOI:10.3389/fonc.2024.1463173
PMID:39507758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11540557/
Abstract

OBJECTIVES

This study evaluated the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for survival outcomes in bladder cancer patients treated with radical cystectomy.

METHODS

Studies assessing NLR's prognostic significance for bladder cancer after radical cystectomy were identified from PubMed, Embase, Web of Science, and Cochrane databases until April 2024. Survival outcomes analyzed included overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), cancer-specific survival (CSS), and progression-free survival (PFS).

RESULTS

The meta-analysis comprised 15 cohort studies with 8,448 patients. Multivariate analysis showed significantly shorter OS, CSS, DFS, and RFS in the high NLR group compared to the low NLR group. However, no significant difference in PFS was observed between the groups.

CONCLUSIONS

NLR serves as an independent prognostic indicator for bladder cancer patients undergoing radical cystectomy, with elevated NLR associated with poorer survival. Further large-scale, prospective studies are warranted to validate the relationship between NLR and prognosis in bladder cancer.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024549573.

摘要

目的

本研究评估了中性粒细胞与淋巴细胞比值（NLR）对接受根治性膀胱切除术的膀胱癌患者生存结局的预后价值。

方法

从PubMed、Embase、Web of Science和Cochrane数据库中检索截至2024年4月评估NLR对根治性膀胱切除术后膀胱癌预后意义的研究。分析的生存结局包括总生存期（OS）、无病生存期（DFS）、无复发生存期（RFS）、癌症特异性生存期（CSS）和无进展生存期（PFS）。

结果

荟萃分析纳入了15项队列研究，共8448例患者。多变量分析显示，高NLR组的OS、CSS、DFS和RFS显著短于低NLR组。然而，两组之间的PFS未观察到显著差异。

结论

NLR是接受根治性膀胱切除术的膀胱癌患者的独立预后指标，NLR升高与较差的生存率相关。有必要进行进一步的大规模前瞻性研究来验证NLR与膀胱癌预后之间的关系。

系统评价注册

https://www.crd.york.ac.uk/PROSPERO/，标识符CRD42024549573。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/ecd291a66139/fonc-14-1463173-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/90a99db43a6b/fonc-14-1463173-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/76910141c1d2/fonc-14-1463173-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/36de6f10d28c/fonc-14-1463173-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/699f9b55e77d/fonc-14-1463173-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/ecd291a66139/fonc-14-1463173-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/90a99db43a6b/fonc-14-1463173-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/76910141c1d2/fonc-14-1463173-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/36de6f10d28c/fonc-14-1463173-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/699f9b55e77d/fonc-14-1463173-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e6/11540557/ecd291a66139/fonc-14-1463173-g005.jpg

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