Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, China.
Department of Breast Surgery, Affiliated Hospital of Jiangnan University, Wuxi, China.
PeerJ. 2024 May 15;12:e17382. doi: 10.7717/peerj.17382. eCollection 2024.
Preoperative inflammatory factors and nutritional status are strongly associated with the prognosis of a variety of cancers. We explored the relationship between preoperative lymphocytes, neutrophils and albumin (LANR) and progression-free survival in breast cancer patients.
The clinical and follow-up data of 200 breast cancer patients were retrospectively analyzed in this study, and the value of LANR was determined as follows: LANR, lymphocytes × albumin/neutrophils. ROC curves, COX proportional risk regression analysis and subgroup analysis were used to assess the prognostic value of LANR in progression-free survival of breast cancer patients.
The median age of the patients was 55.5 years (range 50-62 years). The median follow-up time was 46 months (range 33-55 months). In progression-free survival, the area under the LANR curve was 0.748 and the HR (95% CI) was 0.035 (0.679-0.817). LANR was associated with age ( = 0.02), positive axillary lymph nodes ( < 0.001), TNM stage ( < 0.001) and human epidermal growth factor receptor 2( = 0.004). The results indicated that preoperative LANR may be a reliable predictor of progression-free survival in patients with operable breast cancer.
LANR may be an essential predictor for breast cancer patients and provides a therapeutic basis for clinicians and patients.
术前炎症因子和营养状况与多种癌症的预后密切相关。我们探讨了乳腺癌患者术前淋巴细胞、中性粒细胞和白蛋白（LANR）与无进展生存期之间的关系。
本研究回顾性分析了 200 例乳腺癌患者的临床和随访资料，LANR 值的确定如下：LANR=淋巴细胞×白蛋白/中性粒细胞。采用 ROC 曲线、COX 比例风险回归分析和亚组分析评估 LANR 在乳腺癌患者无进展生存期中的预后价值。
患者的中位年龄为 55.5 岁（范围 50-62 岁）。中位随访时间为 46 个月（范围 33-55 个月）。在无进展生存方面，LANR 曲线下面积为 0.748，HR（95%CI）为 0.035（0.679-0.817）。LANR 与年龄（=0.02）、腋窝淋巴结阳性（<0.001）、TNM 分期（<0.001）和人表皮生长因子受体 2（=0.004）有关。结果表明，术前 LANR 可能是可手术乳腺癌患者无进展生存期的可靠预测指标。
LANR 可能是乳腺癌患者的重要预测指标，为临床医生和患者提供了治疗依据。
