Wnt Signaling: The Next Step on the Road to Anti-Epileptogenic Therapies?
作者信息
Moncion Carolina, West Peter J, Metcalf Cameron S
机构信息
Department of Pharmacology & Toxicology, University of Utah.
出版信息
Epilepsy Curr. 2024 Oct 15;24(5):355-357. doi: 10.1177/15357597241280467. eCollection 2024 Sep-Oct.
Abstract
摘要
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本文引用的文献
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The multifaceted role of Wnt canonical signalling in neurogenesis, neuroinflammation, and hyperexcitability in mesial temporal lobe epilepsy.Wnt 经典信号通路在颞叶内侧癫痫中神经发生、神经炎症和过度兴奋中的多效性作用。
Neuropharmacology. 2024 Jun 15;251:109942. doi: 10.1016/j.neuropharm.2024.109942. Epub 2024 Apr 1.
2
Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy.经典 Wnt 激活剂 Chir99021 可预防海人酸诱导的颞叶癫痫小鼠模型中的癫痫发生。
Exp Neurol. 2024 Jun;376:114767. doi: 10.1016/j.expneurol.2024.114767. Epub 2024 Mar 22.
3
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy.内侧颞叶癫痫患者的成人神经发生和神经胶质发生改变。
Nat Neurosci. 2022 Apr;25(4):493-503. doi: 10.1038/s41593-022-01044-2. Epub 2022 Apr 5.
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Anti-Epileptogenic Effects of Antiepileptic Drugs.抗癫痫药物的抗癫痫作用。
Int J Mol Sci. 2020 Mar 28;21(7):2340. doi: 10.3390/ijms21072340.
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Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy.网络药理学有效调控获得性颞叶癫痫发展的概念验证。
Neurobiol Dis. 2020 Feb;134:104664. doi: 10.1016/j.nbd.2019.104664. Epub 2019 Nov 1.
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