Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, Mumbai, India.
J Microencapsul. 2024 Dec;41(8):818-831. doi: 10.1080/02652048.2024.2423618. Epub 2024 Nov 7.
The dermal route is commonly used to deliver the drugs at the targeted site and achieve maximum therapeutic efficacy. The stratum corneum, the uppermost layer of the skin, presents a significant diffusional barrier for most drugs. Various nanoformulations face challenges such as limited drug absorption and inadequate retention at the targeted site, frequently hindering therapeutic efficacy. Researchers are increasingly exploring innovative strategies that leverage nanotechnology and specialized carriers to address these challenges and enhance the outcomes of dermal medications. A novel drug delivery system, bilosomes, has been designed as a potential vesicular carrier system for the dermal route. Bilosomes are colloidal, lipid-based vesicles stabilized with bile salts, offering greater stability during storage and transportation. The lipid bilayer of bilosomes imparts ultra-flexibility, facilitating penetration through the stratum corneum. This review explores the use of bilosomes in dermal formulations for treating diverse diseases, their developmental techniques, and characterization, and it sheds light on their advantages over traditional lipid nanocarriers.
经皮给药途径常用于将药物递送到靶部位，并实现最大的治疗效果。皮肤的最外层角质层是大多数药物的重要扩散屏障。各种纳米制剂面临着药物吸收有限和在靶部位滞留不足等挑战，这常常会影响治疗效果。研究人员越来越多地探索创新策略，利用纳米技术和专门的载体来应对这些挑战，并提高经皮药物的效果。双层脂质体作为一种潜在的经皮给药载体系统，被设计为一种新型的药物传递系统。双层脂质体是胶体状的，由胆盐稳定的脂质双层组成，在储存和运输过程中提供了更大的稳定性。双层脂质体的脂质双层赋予其超柔韧性，有助于穿透角质层。本文综述了双层脂质体在治疗各种疾病的经皮制剂中的应用、其开发技术和特性，并探讨了其相对于传统脂质纳米载体的优势。
