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LX9211，缓解糖尿病性周围神经病理性疼痛的一颗新星。

LX9211, a rising star for relieving of diabetic peripheral neuropathic pain.

作者信息

Lee Chia-Chin, Ko Fu-Shun, Yen Fu-Shun, Hwu Chii-Min

机构信息

Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Dr. Yen's Clinic, Taoyuan, Taiwan.

出版信息

J Diabetes Investig. 2025 Feb;16(2):176-179. doi: 10.1111/jdi.14342. Epub 2024 Nov 7.

DOI:10.1111/jdi.14342
PMID:39508339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786167/
Abstract

In a multicenter trial, LX9211 significantly reduced pain in diabetic peripheral neuropathy (DPN) patients, with the 10 mg dose showing notable relief by the first week. Although the higher dose was less effective, side effects like dizziness and nausea were generally mild. These findings highlight the importance of exploring both pharmaceutical and natural treatments, such as flavonoids, for managing DPN.

摘要

在一项多中心试验中，LX9211显著减轻了糖尿病周围神经病变（DPN）患者的疼痛，10毫克剂量在第一周就显示出明显的缓解效果。尽管高剂量效果较差，但头晕和恶心等副作用通常较轻。这些发现凸显了探索药物治疗和天然治疗方法（如类黄酮）来管理DPN的重要性。

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本文引用的文献

1
Efficacy and Safety of LX9211 for Relief of Diabetic Peripheral Neuropathic Pain (RELIEF-DPN 1): Results of a Double-Blind, Randomized, Placebo-Controlled, Proof-of-Concept Study.LX9211 治疗糖尿病周围神经性疼痛的疗效和安全性（RELIEF-DPN 1）：一项双盲、随机、安慰剂对照、概念验证研究的结果。
Diabetes Care. 2024 Aug 1;47(8):1325-1332. doi: 10.2337/dc24-0188.
2
Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin.糖尿病肾病和周围神经病变的生物标志物及信号通路：芦丁和槲皮素可能的治疗干预
Diabetol Int. 2023 Dec 19;15(2):145-169. doi: 10.1007/s13340-023-00680-8. eCollection 2024 Apr.
3
Pharmacological Treatment of Diabetic Peripheral Neuropathy: An Update.糖尿病周围神经病变的药物治疗：最新进展
CNS Neurol Disord Drug Targets. 2022;21(10):884-900. doi: 10.2174/1871527320666210303111939.
4
Painful and Painless Diabetic Neuropathies: What Is the Difference?痛性和无痛性糖尿病周围神经病变：有何不同？
Curr Diab Rep. 2019 May 7;19(6):32. doi: 10.1007/s11892-019-1150-5.
5
Diabetic Neuropathy: A Position Statement by the American Diabetes Association.糖尿病神经病变：美国糖尿病协会的立场声明
Diabetes Care. 2017 Jan;40(1):136-154. doi: 10.2337/dc16-2042.
6
Efficacy and Safety of Pregabalin in the Treatment of Patients With Painful Diabetic Peripheral Neuropathy and Pain on Walking.普瑞巴林治疗疼痛性糖尿病周围神经病变及行走疼痛患者的疗效与安全性。
Clin J Pain. 2015 Nov;31(11):946-58. doi: 10.1097/AJP.0000000000000198.
7
A comparative evaluation of amitriptyline and duloxetine in painful diabetic neuropathy: a randomized, double-blind, cross-over clinical trial.阿米替林与度洛西汀治疗糖尿病性神经痛的对比评价：一项随机、双盲、交叉临床试验。
Diabetes Care. 2011 Apr;34(4):818-22. doi: 10.2337/dc10-1793. Epub 2011 Feb 25.
8
A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain.一项比较度洛西汀与安慰剂治疗糖尿病性周围神经病理性疼痛的双盲、随机多中心试验。
Pain Med. 2005 Sep-Oct;6(5):346-56. doi: 10.1111/j.1526-4637.2005.00061.x.
9
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Pain. 2005 Jul;116(1-2):109-18. doi: 10.1016/j.pain.2005.03.029.
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