Li Huimin, Li Pengju, Zhang Jiarui, Lin Ziyi, Bai Lintao, Shen Heyun
Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China.
Nanoscale. 2024 Dec 5;16(47):21697-21730. doi: 10.1039/d4nr03058c.
Achieving accurate and efficient tumor imaging is crucial in the field of tumor treatment, as it facilitates early detection and precise localization of tumor tissues, thereby informing therapeutic strategies and surgical interventions. The optical imaging technology within the second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such as enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal tissue autofluorescence, reduced photon attenuation, and lower tissue scattering. This review explained the design and optimization strategies of nano-agents responsive to the NIR-II window, such as single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, and noble metal nanomaterials. These nano-agents enable non-invasive, deep-tissue imaging with high spatial resolution in the NIR-II window, and their superior optical properties significantly improve the accuracy, efficiency, and versatility of imaging-guided tumor treatments. And we discussed the characteristics and advantages of fluorescence imaging (FL)/photoacoustic imaging (PA) in NIR-II window, providing a comprehensive overview of the latest research progress of different nano-agents in FL/PA imaging-guided tumor therapy. Furthermore, we exhaustively reviewed the latest applications of multifunctional nano-phototherapy technologies carried out by NIR-II light including photothermal therapy (PTT), photodynamic therapy (PDT), and combined modalities like photothermal-chemodynamic therapy (PTT-CDT), photothermal-chemotherapy (PTT-CT), and photothermal- immunotherapy (PTT-IO). These imaging-guided integrated tumor therapy approaches within the NIR-II window have gradually matured over the past decade and are expected to become a safe and effective non-invasive tumor treatment. Finally, we outlined the prospects and challenges of development and innovation of the NIR-II integrated diagnosis and therapy nanoplatform. This review aims to provide insightful perspectives for future advancements in NIR-II optical tumor diagnosis and integrated treatment platforms.
在肿瘤治疗领域，实现准确且高效的肿瘤成像至关重要，因为它有助于肿瘤组织的早期检测和精确定位，从而为治疗策略和手术干预提供依据。第二近红外（NIR-II）窗口内的光学成像技术因其显著优势，如增强的组织穿透深度、优异的信背比（SBR）、最小的组织自发荧光、降低的光子衰减和较低的组织散射，而备受关注。本综述阐述了对NIR-II窗口有响应的纳米制剂的设计和优化策略，如单壁碳纳米管、量子点、镧基纳米材料和贵金属纳米材料。这些纳米制剂能够在NIR-II窗口实现具有高空间分辨率的非侵入性深层组织成像，其优异的光学特性显著提高了成像引导肿瘤治疗的准确性、效率和多功能性。我们还讨论了NIR-II窗口中荧光成像（FL）/光声成像（PA）的特点和优势，全面概述了不同纳米制剂在FL/PA成像引导肿瘤治疗方面的最新研究进展。此外，我们详尽回顾了由NIR-II光进行的多功能纳米光疗技术的最新应用，包括光热疗法（PTT）、光动力疗法（PDT）以及光热-化学动力疗法（PTT-CDT）、光热-化疗（PTT-CT）和光热-免疫疗法（PTT-IO）等联合模式。在过去十年中，这些NIR-II窗口内的成像引导综合肿瘤治疗方法已逐渐成熟，有望成为一种安全有效的非侵入性肿瘤治疗方法。最后，我们概述了NIR-II集成诊断与治疗纳米平台开发与创新的前景和挑战。本综述旨在为NIR-II光学肿瘤诊断和集成治疗平台的未来发展提供有见地的观点。
