Department of Cardiovascular Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Immun Inflamm Dis. 2024 Nov;12(11):e70053. doi: 10.1002/iid3.70053.
Nutrition and inflammation are known factors in chronic pain, but their combined influence is not fully understood. This study investigates the associations between advanced lung cancer inflammation index (ALI) and various types of pain, including joint pain, neck pain, low back pain, and severe headaches and migraines.
In this cross-sectional study, a total of 3842 participants were recruited from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Participants were categorized into three groups based on ALI tertiles: low (≤ 46.982), moderate (> 46.982 and ≤ 70.359), and high (> 70.359). Logistic regression, restricted cubic splines (RCS), and stratified analyses were employed to assess the relationship between ALI and various types of pain.
High ALI consistently correlated with an increased risk of joint pain (fully adjusted odds ratio [OR]: 1.284; 95% confidence interval [CI]: 1.044-1.578) compared to low ALI. However, limited evidence was found in other types of pain. Stratified analyses revealed that high ALI was particularly associated with joint pain in specific demographics, including females (OR: 1.607; 95% CI: 1.205-2.144; p = 0.002), individuals aged ≥ 65 years (OR: 1.914; 95% CI: 1.254-2.923; p = 0.004), and those with a high school diploma (OR: 1.630; 95% CI: 1.171-2.268; p = 0.006). ALI also showed a positive association with multisite pain (p < 0.05), with RCS analysis revealing a linear relationship between ALI and joint pain, escalating beyond 57.85.
This study highlights the association between ALI and joint pain, particularly among females and older individuals. Furthermore, ALI may influence the presence of pain at multiple sites.
营养和炎症是慢性疼痛已知的因素，但它们的综合影响尚不完全清楚。本研究调查了晚期肺癌炎症指数（ALI）与各种类型疼痛之间的关系，包括关节痛、颈痛、腰痛和严重头痛和偏头痛。
本横断面研究共纳入了 1999 年至 2004 年期间全国健康与营养调查（NHANES）中的 3842 名参与者。根据 ALI 三分位将参与者分为三组：低（≤46.982）、中（>46.982 且≤70.359）和高（>70.359）。采用逻辑回归、限制立方样条（RCS）和分层分析评估 ALI 与各种类型疼痛之间的关系。
与低 ALI 相比，高 ALI 与关节痛的风险增加呈一致性相关（完全调整后的比值比 [OR]：1.284；95%置信区间 [CI]：1.044-1.578）。然而，在其他类型的疼痛中，证据有限。分层分析表明，高 ALI 与特定人群的关节痛特别相关，包括女性（OR：1.607；95%CI：1.205-2.144；p=0.002）、年龄≥65 岁的个体（OR：1.914；95%CI：1.254-2.923；p=0.004）和具有高中学历的个体（OR：1.630；95%CI：1.171-2.268；p=0.006）。ALI 还与多部位疼痛呈正相关（p<0.05），RCS 分析显示 ALI 与关节痛之间存在线性关系，超过 57.85 后呈上升趋势。
本研究强调了 ALI 与关节痛之间的关联，尤其是在女性和老年人中。此外，ALI 可能会影响多个部位的疼痛存在。
