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经颅直流电刺激治疗注意缺陷多动障碍的研究进展

Research progress of tDCS in the treatment of ADHD.

作者信息

Huang Ruihan, Liu Yongsheng

机构信息

School of Public Health, Qilu Medical University, Zibo, Shandong, China.

School of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.

出版信息

J Neural Transm (Vienna). 2025 Feb;132(2):237-251. doi: 10.1007/s00702-024-02853-4. Epub 2024 Nov 7.

DOI:10.1007/s00702-024-02853-4
PMID:39508850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11785651/
Abstract

TDCS is one of the most widely used non-invasive neuromodulation techniques, which changes the excitability of local cortical tissue by applying weak continuous direct current to the scalp, effectively improves the attention and concentration of ADHD children, and improves the impulse disorder of patients, but related research is still in its infancy. Based on a review of a large number of existing literatures and an analysis of the pathogenesis and principle of ADHD, this paper summarized the research on tDCS in the treatment of ADHD in recent years from the aspects of treatment mechanism, safety and stimulation parameters, and simply compared the application of tDCS with other non-traumatic neuromodulation techniques in the treatment of ADHD. The future development direction of this technology is further discussed.

摘要

经颅直流电刺激(TDCS)是应用最广泛的非侵入性神经调节技术之一,它通过向头皮施加微弱的连续直流电来改变局部皮质组织的兴奋性,能有效提高多动症儿童的注意力和专注力,并改善患者的冲动障碍,但相关研究仍处于起步阶段。本文在回顾大量现有文献并分析多动症发病机制和原理的基础上,从治疗机制、安全性和刺激参数等方面总结了近年来经颅直流电刺激治疗多动症的研究情况,并简要比较了经颅直流电刺激与其他非创伤性神经调节技术在多动症治疗中的应用。进一步探讨了该技术未来的发展方向。

相似文献

1
Research progress of tDCS in the treatment of ADHD.经颅直流电刺激治疗注意缺陷多动障碍的研究进展
J Neural Transm (Vienna). 2025 Feb;132(2):237-251. doi: 10.1007/s00702-024-02853-4. Epub 2024 Nov 7.
2
Transcranial direct current brain stimulation decreases impulsivity in ADHD.经颅直流电刺激可降低 ADHD 的冲动性。
Brain Stimul. 2018 Sep-Oct;11(5):974-981. doi: 10.1016/j.brs.2018.04.016. Epub 2018 Apr 23.
3
Transcranial Direct Current Stimulation in ADHD: A Systematic Review of Efficacy, Safety, and Protocol-induced Electrical Field Modeling Results.经颅直流电刺激治疗注意缺陷多动障碍:疗效、安全性的系统评价,以及基于方案的电场建模结果。
Neurosci Bull. 2020 Oct;36(10):1191-1212. doi: 10.1007/s12264-020-00501-x. Epub 2020 May 16.
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Transcranial direct current stimulation in attention-deficit hyperactivity disorder: A meta-analysis of neuropsychological deficits.经颅直流电刺激治疗注意缺陷多动障碍:神经心理学缺陷的荟萃分析。
PLoS One. 2019 Apr 12;14(4):e0215095. doi: 10.1371/journal.pone.0215095. eCollection 2019.
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[Noninvasive cerebral stimulation for treatment of ADHD: A review of the literature].[用于治疗注意力缺陷多动障碍的非侵入性脑刺激:文献综述]
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Transcranial Direct Current Stimulation vs Sham for the Treatment of Inattention in Adults With Attention-Deficit/Hyperactivity Disorder: The TUNED Randomized Clinical Trial.经颅直流电刺激与假刺激治疗成人注意缺陷多动障碍注意不集中:TUNED 随机临床试验。
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Positive effects of transcranial direct current stimulation in adult patients with attention-deficit/hyperactivity disorder - A pilot randomized controlled study.经颅直流电刺激对成人注意缺陷多动障碍患者的积极影响——一项初步随机对照研究。
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Baseline brain volume predicts home-based transcranial direct current stimulation effects on inattention in adults with attention-deficit/hyperactivity disorder.基线脑容量可预测家庭经颅直流电刺激对注意缺陷多动障碍成人注意力不集中的影响。
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Transcranial direct current stimulation improves long-term memory deficits in an animal model of attention-deficit/hyperactivity disorder and modulates oxidative and inflammatory parameters.经颅直流电刺激改善注意缺陷多动障碍动物模型的长期记忆缺陷,并调节氧化和炎症参数。
Brain Stimul. 2018 Jul-Aug;11(4):743-751. doi: 10.1016/j.brs.2018.04.001. Epub 2018 Apr 5.
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A systematic review of randomized controlled trials on efficacy and safety of transcranial direct current stimulation in major neurodevelopmental disorders: ADHD, autism, and dyslexia.一项关于经颅直流电刺激治疗主要神经发育障碍(ADHD、自闭症和阅读障碍)的疗效和安全性的随机对照试验的系统评价。
Brain Behav. 2022 Sep;12(9):e2724. doi: 10.1002/brb3.2724. Epub 2022 Aug 8.

本文引用的文献

1
Cognitive Functions following Trigeminal Neuromodulation.三叉神经调节后的认知功能
Biomedicines. 2023 Aug 27;11(9):2392. doi: 10.3390/biomedicines11092392.
2
Transcranial random noise stimulation combined with cognitive training for treating ADHD: a randomized, sham-controlled clinical trial.经颅随机噪声刺激联合认知训练治疗 ADHD:一项随机、假刺激对照临床试验。
Transl Psychiatry. 2023 Aug 2;13(1):271. doi: 10.1038/s41398-023-02547-7.
3
Safety and Tolerability of tDCS across Different Ages, Sexes, Diagnoses, and Amperages: A Randomized Double-Blind Controlled Study.经颅直流电刺激(tDCS)在不同年龄、性别、诊断及电流强度下的安全性与耐受性:一项随机双盲对照研究。
J Clin Med. 2023 Jun 28;12(13):4346. doi: 10.3390/jcm12134346.
4
ADHD in children and adolescents: Review of current practice of non-pharmacological and behavioural management.儿童和青少年的注意力缺陷多动障碍:非药物和行为管理的当前实践综述
AIMS Public Health. 2023 Feb 7;10(1):35-51. doi: 10.3934/publichealth.2023004. eCollection 2023.
5
Modulation effect of non-invasive transcranial ultrasound stimulation in an ADHD rat model.非侵入性经颅超声刺激对注意缺陷多动障碍大鼠模型的调节作用
J Neural Eng. 2023 Jan 18;20(1). doi: 10.1088/1741-2552/acb014.
6
Biological and Neurobiological Mechanisms of Transcranial Direct Current Stimulation.经颅直流电刺激的生物学和神经生物学机制
Iran J Psychiatry. 2022 Jul;17(3):350-355. doi: 10.18502/ijps.v17i3.9735.
7
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.六种神经发育和精神障碍的皮质厚度变化的协调。
Nat Commun. 2022 Nov 11;13(1):6851. doi: 10.1038/s41467-022-34367-6.
8
The influence of tDCS on perceived bouncing/streaming.经颅直流电刺激对感知反弹/流畅性的影响。
Exp Brain Res. 2023 Jan;241(1):59-66. doi: 10.1007/s00221-022-06505-5. Epub 2022 Nov 10.
9
ADHD Diagnostic Trends: Increased Recognition or Overdiagnosis?ADHD 诊断趋势:识别增加还是过度诊断?
Mo Med. 2022 Sep-Oct;119(5):467-473.
10
Multi-modal investigation of transcranial ultrasound-induced neuroplasticity of the human motor cortex.多模态研究经颅超声刺激人类运动皮层的神经可塑性。
Brain Stimul. 2022 Nov-Dec;15(6):1337-1347. doi: 10.1016/j.brs.2022.10.001. Epub 2022 Oct 11.