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比较急性右结肠和乙状结肠憩室炎的手术治疗和结局:一项法国全国回顾性队列研究。

Comparison of surgical management and outcomes of acute right colic and sigmoid diverticulitis: a French national retrospective cohort study.

机构信息

Department of Digestive, Oncological, Endocrine, Hepato-Biliary and Pancreatic Surgery, and Liver Transplantation, Colorectal Surgery Unit, Trousseau Hospital, University Hospital of Tours, Avenue de la République, 37044, Tours, France.

Department of Surgery Department, Amiens University Hospital, Amiens, France.

出版信息

Tech Coloproctol. 2024 Nov 7;28(1):149. doi: 10.1007/s10151-024-03024-z.

DOI:10.1007/s10151-024-03024-z
PMID:39508963
Abstract

BACKGROUND

Acute right colic diverticulitis (ARD) is less frequent in Western countries than acute sigmoid diverticulitis (ASD). We aimed to compare the management of ARD and ASD operated on in emergency.

METHODS

All consecutive patients who had emergency surgery for ASD and ARD (2010-2021) were included in a retrospective, multicenter, cohort study. Patients were identified from databases in French centers that were members of the French Surgical Association. Emergency surgery was performed during the same hospitalization for peritonitis or after failure of conservative treatment. Early and late postoperative outcomes were studied.

RESULTS

A total of 2297 patients were included with 2256 (98.2%) ASD and 41 (1.8%) ARD patients. Baseline characteristics were similar. Overall, patients were rated Hinchey 3-4 (63.9%, n = 1468, p = 0.287). ARD was more often treated with resection and anastomosis, protected or not (53.7%, n = 22), whereas ASD was mainly treated with resection and terminal ostomy (62.5% (n = 1409), p < 0.001). Median operative time was shorter for ARD (120 vs 146 min, p = 0.04). The group of ARD patients showed a higher prevalence of Clavien III/IV complications compared to the group of ASD patients, although no statistically significant difference was observed (41.5%, n = 17 vs. 27.6%, n = 620, p = 0.054). However 90-day mortality only happened in ASD patients (9.8%, n = 223 vs 0, p = 0.03). ARD patients had more diverticulitis recurrence (46.3%, n = 19 vs 13.4%, n = 303, p < 0.001). Multivariate analysis identified female sex as a protective factor for recurrence [odds ratio (OR) 0.55, p < 0.001] and ARD as a risk factor (OR 8.85, p < 0.001).

CONCLUSION

Operated on in emergency, ARDs have more resection anastomosis, with a similar rate of complications, less mortality, and more recurrence of diverticulitis than ASD.

摘要

背景

急性右结肠憩室炎(ARD)在西方国家比急性乙状结肠憩室炎(ASD)少见。我们旨在比较急诊手术治疗 ARD 和 ASD 的效果。

方法

所有因 ASD 和 ARD 接受急诊手术的连续患者(2010-2021 年)均纳入一项回顾性、多中心队列研究。患者从法国外科协会成员的法国中心数据库中确定。急诊手术是在腹膜炎或保守治疗失败时进行的。研究了早期和晚期术后结果。

结果

共纳入 2297 例患者,其中 2256 例(98.2%)为 ASD 患者,41 例(1.8%)为 ARD 患者。基线特征相似。总体而言,患者的 Hinchey 分级为 3-4 级(63.9%,n=1468,p=0.287)。ARD 更常采用保护或不保护的切除吻合术(53.7%,n=22)治疗,而 ASD 主要采用切除和末端造口术(62.5%(n=1409),p<0.001)治疗。ARD 的手术时间中位数较短(120 分钟与 146 分钟,p=0.04)。与 ASD 患者相比,ARD 患者的 Clavien III/IV 并发症发生率更高,但差异无统计学意义(41.5%,n=17 与 27.6%,n=620,p=0.054)。然而,只有 ASD 患者在 90 天内死亡(9.8%,n=223 与 0,p=0.03)。ARD 患者的憩室炎复发率更高(46.3%,n=19 与 13.4%,n=303,p<0.001)。多变量分析确定女性为复发的保护因素[比值比(OR)0.55,p<0.001],ARD 为危险因素(OR 8.85,p<0.001)。

结论

在急诊手术中,ARD 行更多的切除吻合术,并发症发生率相似,死亡率较低,憩室炎复发率高于 ASD。

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本文引用的文献

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Risk factors for emergency surgery for diverticulitis: A retrospective multicentric French study at 41 hospitals.憩室炎急诊手术的风险因素:41 家医院的回顾性法国多中心研究。
Surgery. 2024 Jun;175(6):1508-1517. doi: 10.1016/j.surg.2024.02.009. Epub 2024 Apr 12.
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Risk factors for severe morbidity and definitive stoma after elective surgery for sigmoid diverticulitis: a multicenter national cohort study.择期手术治疗乙状结肠憩室炎后发生严重并发症和确定性造口的风险因素:一项多中心全国队列研究。
Tech Coloproctol. 2024 Feb 19;28(1):34. doi: 10.1007/s10151-023-02906-y.
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Acute Colonic Diverticulitis: CT Findings, Classifications, and a Proposal of a Structured Reporting Template.
急性结肠憩室炎:CT表现、分类及结构化报告模板的建议
Diagnostics (Basel). 2023 Dec 8;13(24):3628. doi: 10.3390/diagnostics13243628.
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Recurrence of diverticulitis after prophylactic sigmoidectomy: an underestimated problem?预防性乙状结肠切除术后憩室炎复发:一个被低估的问题?
Colorectal Dis. 2023 Apr;25(4):757-763. doi: 10.1111/codi.16426. Epub 2022 Dec 4.
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Management and long-term outcomes of acute right colonic diverticulitis and risk factors of recurrence.急性右半结肠憩室炎的治疗及长期转归和复发的危险因素
BMC Surg. 2022 Apr 7;22(1):132. doi: 10.1186/s12893-022-01578-z.
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Meta-analysis of the demographic and prognostic significance of right-sided versus left-sided acute diverticulitis.右半侧与左半侧急性憩室炎的人口统计学和预后意义的荟萃分析。
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Emergency surgery comparison of right versus left acute colonic diverticulitis: A 10-year outcome analysis.右半与左半急性结肠憩室炎的急诊手术比较:一项10年的结果分析。
Surgeon. 2021 Jun;19(3):150-155. doi: 10.1016/j.surge.2020.04.007. Epub 2020 Jul 18.
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