Dewan Vikrant, Mahich Swati, Sachan Deepak
Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER) & Associated Dr. Ram Manohar Lohia (RML) Hospital, New Delhi, India.
Indian J Pediatr. 2025 Apr;92(4):393-395. doi: 10.1007/s12098-024-05281-0. Epub 2024 Nov 7.
Subacute sclerosing panencephalitis (SSPE) is a devastating fatal condition caused by mutated measles virus. It predominantly affects children of younger age and invariably leads to mortality. Though reported rarely, the disease continues to cause significant morbidity in children. The authors conducted an observational study in which CSF was withdrawn from 24 cases of confirmed SSPE (Dyken's criteria) and interleukin levels were estimated by ELISA method. On analysis, IL-12 was significantly elevated in CSF of stage 3 SSPE patients with p value of 0.02. It was elevated in only 2 patients of stage 3 which is the major limitation of this study. No significant difference was seen in IL-17 and interferon-γ levels between different stages of SSPE in serum and CSF. This study highlights the significant elevation of IL-12 cytokine while other studied cytokines (IL-17/ IFN-γ) were not significantly altered in these patients.
亚急性硬化性全脑炎（SSPE）是一种由变异麻疹病毒引起的毁灭性致命疾病。它主要影响年幼的儿童，最终必然导致死亡。尽管报告的病例很少，但该疾病仍继续在儿童中造成严重发病。作者进行了一项观察性研究，从24例确诊的SSPE（戴肯标准）病例中抽取脑脊液，并通过酶联免疫吸附测定法评估白细胞介素水平。分析发现，3期SSPE患者脑脊液中的IL-12显著升高，p值为0.02。仅在3期的2例患者中升高，这是本研究的主要局限性。在血清和脑脊液中，SSPE不同阶段的IL-17和干扰素-γ水平没有显著差异。这项研究突出了IL-12细胞因子的显著升高，而其他研究的细胞因子（IL-17/IFN-γ）在这些患者中没有显著变化。
