Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai Yuhuangding Hospital, Yantai, China.
J Alzheimers Dis. 2024 Nov;102(2):347-358. doi: 10.1177/13872877241289790. Epub 2024 Nov 8.
Alzheimer's disease (AD) can be optimally managed from a healthcare point of view if detected at a prodromal stage. Amnestic mild cognitive impairment (MCI) is known as prodromal AD, has attracted extensive attention and research.
To identify the differences in cognitive function and structural magnetic resonance imaging (MRI) features between men and women with MCI on the basis of A/T/N classification system ("A" means amyloid-β biomarker, "T" means tau biomarker, and "N" means neurodegeneration biomarker as determined by clinical imaging (e.g., positron emission tomography, magnetic resonance imaging (MRI)) or by the measurement of total tau protein (T-tau) in the cerebrospinal fluid (CSF)) and to further explore the correlation between them.
406 MCI subjects were selected from the Alzheimer's Disease Neuroimaging Initiative database and divided into male and female MCI groups. Differences in demographic characteristics, biomarkers, cognitive assessment performance, and regions of interest (ROIs) of structural MRI were compared between the two groups. The correlations between brain structural changes quantified by MRI and cognitive abilities were investigated through linear regression models.
Compared with male MCI subjects, females had significantly higher T-tau concentration in CSF. There were significant differences in ROIs between the sex groups. In the male MCI group, the average cortical thicknesses of the right posterior cingulate, right anterior cingulate and right supramarginal gyrus were more closely correlated with cognitive function. In the female MCI group, the volume of the right rostral anterior cingulate, and the surface area and average cortical thickness of the right isthmus of the cingulate gyrus were more closely correlated with cognitive function.
Based on A/T/N classification system, the structural MRI data analysis was closely correlated with the difference of cognitive function from patients with prodromal AD in a sex-dependent manner.
从医疗保健的角度来看，如果在前驱阶段发现，阿尔茨海默病（AD）可以得到最佳的管理。遗忘型轻度认知障碍（MCI）被认为是前驱 AD，已引起广泛关注和研究。
根据 A/T/N 分类系统（“A”表示淀粉样蛋白-β生物标志物，“T”表示 tau 生物标志物，“N”表示神经退行性生物标志物，由临床成像（例如正电子发射断层扫描、磁共振成像（MRI））或通过测量脑脊液（CSF）中的总 tau 蛋白（T-tau）确定），确定男性和女性 MCI 患者在认知功能和结构磁共振成像（MRI）特征方面的差异，并进一步探讨它们之间的相关性。
从阿尔茨海默病神经影像学倡议数据库中选择 406 名 MCI 受试者，并将其分为男性和女性 MCI 组。比较两组间人口统计学特征、生物标志物、认知评估表现和结构 MRI 感兴趣区（ROI）的差异。通过线性回归模型研究 MRI 量化的脑结构变化与认知能力之间的相关性。
与男性 MCI 患者相比，女性 CSF 中的 T-tau 浓度显著升高。两组间 ROI 存在显著差异。在男性 MCI 组中，右侧后扣带回、右侧前扣带回和右侧缘上回的平均皮质厚度与认知功能更为密切相关。在女性 MCI 组中，右侧额前扣带回的体积，以及扣带回峡部的表面积和平均皮质厚度与认知功能更为密切相关。
基于 A/T/N 分类系统，结构 MRI 数据分析与前驱 AD 患者认知功能差异密切相关，且存在性别依赖性。
