Safari Roya, Shakurnia Abdolhussein, Ghadiri Ata, Rajaei Elham, Mowla Karim, Haidari Maryam
Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cellular and Molecular Research Centre, Medical Basic and Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Adv Biomed Res. 2024 Sep 23;13:77. doi: 10.4103/abr.abr_359_23. eCollection 2024.
Psoriatic arthritis (PsA) is a systemic auto-immune condition characterized by diverse and distinctive inflammation, affecting both musculoskeletal and extra-articular systems. This study aims to investigate the role of regulatory T-cells (Tregs), specifically the CD4+CD25+/high CD127-/low subset, in PsA pathogenesis, and their potential as biomarkers and therapeutic targets.
In a case-control study involving 40 PsA patients and 25 healthy individuals, CD4+ CD25+/high CD127-/low Tregs were analyzed in peripheral blood mononuclear cells (PBMCs) using flow cytometry. Disease activity was assessed using the Disease Activity in Psoriatic Arthritis (DAPSA) score.
We observed a significant positive correlation between Treg levels and the DAPSA score ( = 0.02) in non-treated PsA patients. Additionally, patient age showed a significant positive correlation with erythrocyte sedimentation rate in the same group ( = 0.04), emphasizing the potential influence of Tregs on disease activity and age-related effects on inflammatory markers in PsA.
While not revealing significant differences in Treg populations, our research underscores the importance of considering specific Treg subsets in PsA. These subsets may respond differently to disease micro-environments and treatments, affecting disease progression. This study contributes to the broader comprehension of immune dysregulation in auto-immune diseases and suggests that further investigation into Treg subsets' function and count is warranted. Such insights may lead to more tailored therapeutic approaches for PsA patients.
银屑病关节炎（PsA）是一种全身性自身免疫性疾病，其特征为多样且独特的炎症，会影响肌肉骨骼系统和关节外系统。本研究旨在调查调节性T细胞（Tregs），特别是CD4 + CD25 + /高CD127 - /低亚群，在PsA发病机制中的作用，以及它们作为生物标志物和治疗靶点的潜力。
在一项病例对照研究中，纳入了40例PsA患者和25名健康个体，使用流式细胞术分析外周血单个核细胞（PBMCs）中的CD4 + CD25 + /高CD127 - /低Tregs。使用银屑病关节炎疾病活动度（DAPSA）评分评估疾病活动度。
我们观察到在未治疗的PsA患者中，Treg水平与DAPSA评分之间存在显著正相关（ = 0.02）。此外，在同一组中患者年龄与红细胞沉降率之间存在显著正相关（ = 0.04），这强调了Tregs对疾病活动度的潜在影响以及年龄对PsA炎症标志物的影响。
虽然我们的研究未揭示Treg群体存在显著差异，但强调了在PsA中考虑特定Treg亚群的重要性。这些亚群可能对疾病微环境和治疗有不同反应，从而影响疾病进展。本研究有助于更广泛地理解自身免疫性疾病中的免疫失调，并表明有必要进一步研究Treg亚群的功能和数量。这些见解可能会为PsA患者带来更具针对性的治疗方法。
