钙卫蛋白与ST段抬高型心肌梗死患者左心室射血分数降低及心律失常的发生相关。
Calprotectin Correlates with Reduced Level of LVEF and Occurrence of Cardiac Arrhythmia in STEMI Patients.
作者信息
Haybar Habib, Ramezani Babak, Assareh Ahmad Reza, Kardooni Ali, Azizidoost Shirin
机构信息
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Cardiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Adv Biomed Res. 2024 Sep 23;13:90. doi: 10.4103/abr.abr_438_23. eCollection 2024.
BACKGROUND
Calprotectin is recognized as a promising prognostic as well as a diagnostic marker of cardiac disorders. In the present study, we aimed to survey the efficiency of serum calprotectin levels in anticipating the severity of coronary artery disease (CAD) along with in-hospital major adverse cardiovascular events (MACE) in patients with ST-segment elevation (STEMI) underlying primary percutaneous coronary intervention (PCI).
MATERIALS AND METHODS
A total of 97 patients with STEMI participated and were evaluated for in-hospital MACE for possible correlation with serum calprotectin.
RESULTS
Increased levels of serum calprotectin showed positive and negative correlation with severity of coronary arteries and left ventricular ejection fraction (LVEF) of STEMI patients, respectively. Regarding in-hospital MACE, only arrhythmia showed a significant relationship in patients with high calprotectin levels.
CONCLUSION
High calprotectin levels may be a prognostic marker for occluded artery and LVEF in STEMI patients.
背景
钙卫蛋白被认为是一种有前景的心脏疾病预后及诊断标志物。在本研究中，我们旨在调查血清钙卫蛋白水平在预测ST段抬高型心肌梗死（STEMI）患者接受直接经皮冠状动脉介入治疗（PCI）时冠状动脉疾病（CAD）的严重程度以及院内主要不良心血管事件（MACE）方面的效能。
材料与方法
共有97例STEMI患者参与研究，并对其进行院内MACE评估，以探讨其与血清钙卫蛋白的可能相关性。
结果
血清钙卫蛋白水平升高分别与STEMI患者冠状动脉严重程度及左心室射血分数（LVEF）呈正相关和负相关。关于院内MACE，仅心律失常在高钙卫蛋白水平患者中显示出显著相关性。
结论
高钙卫蛋白水平可能是STEMI患者动脉闭塞和LVEF的预后标志物。
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