Tao Yun, Wu Yaxun, Shen Rong, He Song, Miao Xiaobing
Department of Pathology, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu 226361, P.R. China.
Department of Clinical Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226006, P.R. China.
Oncol Lett. 2024 Oct 29;29(1):37. doi: 10.3892/ol.2024.14783. eCollection 2025 Jan.
As a cytoskeletal protein, the four and a half LIM domain protein 1 (FHL1) is widely expressed in various cells, particularly skeletal and cardiac muscle cells. FHL1 is involved in the development of the skeletal muscle and myocardium, regulations of gene transcription and thyroid function, and other physiological processes. Its expression is closely related to numerous diseases, such as skeletal muscle disease and viral infections. With the advances in research, the role of FHL1 in the development of tumors is also being revealed. The mechanism of FHL1 in the regulation of tumor growth is complex and is becoming a research focus. It is also expected to become a potential target for tumor therapy. Therefore, the present article reviewed the progress in research on the role of FHL1 in cancer.
作为一种细胞骨架蛋白，四又二分之一LIM结构域蛋白1（FHL1）在各种细胞中广泛表达，尤其是在骨骼肌和心肌细胞中。FHL1参与骨骼肌和心肌的发育、基因转录调控和甲状腺功能以及其他生理过程。其表达与多种疾病密切相关，如骨骼肌疾病和病毒感染。随着研究的进展，FHL1在肿瘤发生发展中的作用也逐渐被揭示。FHL1调控肿瘤生长的机制复杂，正成为研究热点。它也有望成为肿瘤治疗的潜在靶点。因此，本文综述了FHL1在癌症中作用的研究进展。
