Scherer H, Holtmann S
Laryngol Rhinol Otol (Stuttg). 1986 Jan;65(1):37-8.
After gas sterilisation of synthetic materials, some traces of the gases employed (ethylene oxide; formaldehyde) can remain in the sterilised material, and, in the case of moist materials, in drops of water. These gases are carcinogenic and, in case of contact to tissue, can lead to fibrinous inflammation and consequently to stenotising scars. Two cases of laryngotracheitis are described, in which insufficiently aired tracheal tubes were used. On contact with material containing chloride ions, e.g. PVC or body fluids, ethylene oxid can be converted to highly toxic ethylene chlorohydrine. For this reason, it is prohibited to sterilise synthetics containing chlorine ions with ethylene oxide.
合成材料经气体灭菌后,所使用的某些气体(环氧乙烷;甲醛)痕迹可能残留在灭菌后的材料中,对于潮湿材料,还可能残留在水滴中。这些气体具有致癌性,与组织接触时,可导致纤维蛋白性炎症,进而形成狭窄性瘢痕。本文描述了两例喉气管炎病例,其中使用了通气不足的气管导管。环氧乙烷与含氯离子的材料(如聚氯乙烯或体液)接触时,可转化为剧毒的氯乙醇。因此,禁止使用环氧乙烷对含氯离子的合成材料进行灭菌。