Fadl Asmaa, Leask Andrew
College of Dentistry, University of Saskatchewan, 105 Wiggins Rd, Saskatoon, SK, S7H 2E5, Canada.
College of Dentistry, University of Saskatchewan, 105 Wiggins Rd, Saskatoon, SK, S7H 2E5, Canada.
J Oral Biosci. 2025 Mar;67(1):100587. doi: 10.1016/j.job.2024.100587. Epub 2024 Nov 8.
Fibrotic responses in the gingiva are characterized by their hyperproliferative nature instead of scar tissue formation. Clinically, these conditions appear as "gingival overgrowth" (GO), which can be of drug-induced or genetic origin. Despite surgical removal, GO can recur. Therefore, non-invasive methods of treating GO are required. In other fibrotic systems, the matricellular protein CCN2 represents a potential therapeutic target. However, CCN2 has been relatively understudied in the context of GO.
Herein, we describe what is known regarding CCN2 expression in GO and gingival fibroblasts. Specifically, CCN2 is induced by agents that promote fibrogenesis in the oral cavity, such as transforming growth factor-β, and drugs that promote GO, such as cyclosporine, nifedipine, and phenytoin.
Although little is known regarding the possible function of CCN2 in GO, given the correlation between CCN2 expression and GO recurrence, we hope that this review will inspire further research on this topic.
牙龈中的纤维化反应具有过度增殖的特性，而非形成瘢痕组织。临床上，这些情况表现为“牙龈增生”（GO），其可能由药物诱导或遗传因素引起。尽管手术切除后，GO仍可能复发。因此，需要非侵入性的方法来治疗GO。在其他纤维化系统中，基质细胞蛋白CCN2是一个潜在的治疗靶点。然而，在GO的背景下，CCN2的研究相对较少。
在此，我们描述了关于GO和牙龈成纤维细胞中CCN2表达的已知情况。具体而言，CCN2由促进口腔纤维化的因子诱导，如转化生长因子-β，以及促进GO的药物，如环孢素、硝苯地平和苯妥英。
尽管关于CCN2在GO中可能的功能知之甚少，但鉴于CCN2表达与GO复发之间的相关性，我们希望这篇综述能激发对该主题的进一步研究。
