Chen Matthew, Weichert Maggie, Guo William, Ruzic Robert, Briley James
Department of Dermatology, Stony Brook Dermatology, Stony Brook, New York.
Department of Dermatology, Stony Brook Dermatology, Stony Brook, New York.
J Am Acad Dermatol. 2025 Mar;92(3):554-555. doi: 10.1016/j.jaad.2024.10.057. Epub 2024 Nov 7.
Minoxidil, traditionally used as an antihypertensive, is now widely used for treating various forms of alopecia due to its vasodilatory effects. While topical minoxidil has been the standard treatment, low-dose oral minoxidil (LDOM) is emerging as an effective alternative. This study investigates LDOM's potential hypotensive effects.
Studies were selected based on criteria such as the use of LDOM (≤5 mg/day) and reporting on blood pressure changes. Mean differences (MDs) were calculated for mean arterial pressure (MAP), systolic blood pressure, diastolic blood pressure, and heart rate.
LDOM did not significantly alter systolic blood pressure (MD: -0.13, 95% CI: -2.67-2.41) or diastolic blood pressure (MD: -1.25, 95% CI: -3.21-0.71). Though MAP was not significantly altered, there was a strong tendency toward decreased MAP (MD: -1.92, 95% CI: -4.00-0.17). There was a significant increase in heart rate (MD: 2.67, 95% CI: 0.34-5.01). Hypotensive symptoms were reported in 119 patients (5.0%), but no hypotensive episodes were observed. Hypertrichosis was the most frequent side effect, leading to 34.6% of discontinuations.
Studies lacked control groups and showed variability in dosing regimens and blood pressure monitoring.
LDOM appears to be a safe treatment for alopecia with no significant impact on blood pressure.
米诺地尔传统上用作抗高血压药物，由于其血管舒张作用，现在广泛用于治疗各种形式的脱发。虽然局部用米诺地尔一直是标准治疗方法，但低剂量口服米诺地尔（LDOM）正成为一种有效的替代方法。本研究调查了LDOM的潜在降压作用。
根据使用LDOM（≤5毫克/天）和报告血压变化等标准选择研究。计算平均动脉压（MAP）、收缩压、舒张压和心率的平均差异（MDs）。
LDOM未显著改变收缩压（MD：-0.13，95%CI：-2.67-2.41）或舒张压（MD：-1.25，95%CI：-3.21-0.71）。虽然MAP没有显著改变，但有强烈的MAP下降趋势（MD：-1.92，95%CI：-4.00-0.17）。心率显著增加（MD：2.67，95%CI：0.34-5.01）。119名患者（5.0%）报告有低血压症状，但未观察到低血压发作。多毛症是最常见的副作用，导致34.6%的患者停药。
研究缺乏对照组，给药方案和血压监测存在差异。
LDOM似乎是一种安全的脱发治疗方法，对血压无显著影响。
