Chen Peiying, Li Xiaoxu, Zhang Yiwen, Wang Houpeng, Yu Yunke, Wu Chao, Jia Le, Zhang Jianjun
College of Life Science, Shandong Agricultural University, Taian 271018, China; Shandong Ocean Agricultural Development Co. LTD, Jining 272600, China.
College of Life Science, Shandong Agricultural University, Taian 271018, China.
Int J Biol Macromol. 2024 Dec;282(Pt 6):137370. doi: 10.1016/j.ijbiomac.2024.137370. Epub 2024 Nov 7.
The study was aimed to develop natural non-toxic substances to prevent LPS-induced liver damages and its complications. In present work, a pyranose polysaccharide of Oudemansiella radicata polysaccharides (ORP) with typical characteristics of α-type glycosidic linkage was isolated from the O. radicata fruiting body by physico-chemical analysis, and the potential impact against LPS-induced liver damage were performed in mice model. The results demonstrated that ORP showed significant hepatoprotective effects through its potential anti-oxidative, anti-inflammatory and anti-apoptosis activities via regulating the TLR4/NF-κB and Bax/Bcl-2 signaling pathway, independently or synergistically. These findings had established a robust theoretical framework for promoting the comprehensive utilization of ORP as supplements in the development of functional foods or drugs targeting LPS-induced liver damage and its associated complications.
本研究旨在开发天然无毒物质以预防脂多糖（LPS）诱导的肝损伤及其并发症。在目前的工作中，通过物理化学分析从长根奥德蘑子实体中分离出一种具有典型α型糖苷键特征的吡喃糖多糖——长根奥德蘑多糖（ORP），并在小鼠模型中研究其对LPS诱导的肝损伤的潜在影响。结果表明，ORP通过调节TLR4/NF-κB和Bax/Bcl-2信号通路，独立或协同发挥潜在的抗氧化、抗炎和抗凋亡活性，从而显示出显著的肝保护作用。这些发现为促进ORP作为功能性食品或针对LPS诱导的肝损伤及其相关并发症的药物开发中的补充剂的综合利用建立了坚实的理论框架。
