• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对[具体植物名称]乙醇提取物中富集的活性成分进行广泛靶向代谢组学和网络药理学分析。 需注意，你提供的原文不完整，缺少具体植物名称。

Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of .

作者信息

Wu Zhi, Zhao Jin, Zhu Shuang, Chen Mengxing, Wu Dan, Wu Yiyou, Lin Junbin, Miao Renyun, Feng Rencai, Li Xiang, Gan Bingcheng, Wang Tao

机构信息

Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science & Technology Center, Chengdu 610213, China.

College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.

出版信息

Foods. 2025 Aug 14;14(16):2820. doi: 10.3390/foods14162820.

DOI:10.3390/foods14162820
PMID:40870733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12385618/
Abstract

ethanolic extract (ORE) was prepared via ultrasonication-assisted ethanolic extraction and enriched through silica gel and macroporous adsorption resin chromatography to afford a non-/weakly polar fraction (ORE-S) and a polar fraction (ORE-N), respectively. This study aimed to (1) quantify major bioactive components (e.g., polyphenols, alkaloids, and terpenes) in ORE-S and ORE-N, (2) assess their antioxidant activities, (3) correlate compositional differences with antioxidant function, and (4) identify key antioxidant compounds along with their potential mechanisms of action. By integrating widely targeted metabolomics with network pharmacology, we not only elucidated how enrichment methods influence the antioxidant properties of ORE but also demonstrated the potential of ORE-N as a valuable source of bioactive compounds and natural antioxidants.

摘要

乙醇提取物（ORE）通过超声辅助乙醇提取法制备，并分别通过硅胶和大孔吸附树脂色谱法进行富集，得到一个非/弱极性组分（ORE-S）和一个极性组分（ORE-N）。本研究旨在：（1）定量测定ORE-S和ORE-N中的主要生物活性成分（如多酚、生物碱和萜类）；（2）评估它们的抗氧化活性；（3）将成分差异与抗氧化功能相关联；（4）鉴定关键抗氧化化合物及其潜在作用机制。通过将广泛靶向代谢组学与网络药理学相结合，我们不仅阐明了富集方法如何影响ORE的抗氧化特性，还证明了ORE-N作为生物活性化合物和天然抗氧化剂宝贵来源的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/90c9b6849778/foods-14-02820-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/74719929716d/foods-14-02820-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/0a9be8b097a3/foods-14-02820-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/985c387179af/foods-14-02820-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/a1f7fe95bb49/foods-14-02820-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/f788fc3832c4/foods-14-02820-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/e3d43654c188/foods-14-02820-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/212e6976c0ea/foods-14-02820-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/90c9b6849778/foods-14-02820-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/74719929716d/foods-14-02820-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/0a9be8b097a3/foods-14-02820-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/985c387179af/foods-14-02820-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/a1f7fe95bb49/foods-14-02820-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/f788fc3832c4/foods-14-02820-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/e3d43654c188/foods-14-02820-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/212e6976c0ea/foods-14-02820-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6595/12385618/90c9b6849778/foods-14-02820-g008.jpg

相似文献

1
Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of .对[具体植物名称]乙醇提取物中富集的活性成分进行广泛靶向代谢组学和网络药理学分析。 需注意，你提供的原文不完整，缺少具体植物名称。
Foods. 2025 Aug 14;14(16):2820. doi: 10.3390/foods14162820.
2
OR-FCOS: an enhanced fully convolutional one-stage approach for growth stage identification of Oudemansiella raphanipes.OR-FCOS：一种用于识别萝卜丝膜菌生长阶段的增强型全卷积单阶段方法。
Sci Rep. 2025 Jul 15;15(1):25576. doi: 10.1038/s41598-025-09303-5.
3
Evidences for action of icariin on depressive behavior in prenatal stress offspring rats and mechanism by integrating metabolomics and network pharmacology.淫羊藿苷对产前应激子代大鼠抑郁行为的作用及基于代谢组学和网络药理学的作用机制研究
Phytomedicine. 2025 Oct;146:157132. doi: 10.1016/j.phymed.2025.157132. Epub 2025 Aug 5.
4
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
5
Antioxidants for male subfertility.用于男性生育力低下的抗氧化剂。
Cochrane Database Syst Rev. 2014(12):CD007411. doi: 10.1002/14651858.CD007411.pub3. Epub 2014 Dec 15.
6
Understanding mechanisms of -derived exosome-like nanoparticles against breast cancer through an integrated metabolomics and network pharmacology analysis.通过综合代谢组学和网络药理学分析了解源自 - 的外泌体样纳米颗粒抗乳腺癌的机制。
Front Chem. 2025 Jun 6;13:1559758. doi: 10.3389/fchem.2025.1559758. eCollection 2025.
7
Patient buy-in to social prescribing through link workers as part of person-centred care: a realist evaluation.患者通过联络人员接受社会处方作为以患者为中心的护理的一部分：一项现实主义评价。
Health Soc Care Deliv Res. 2024 Sep 25:1-17. doi: 10.3310/ETND8254.
8
Properties of Plant Extracts from Adriatic Maritime Zone for Innovative Food and Packaging Applications: Insights into Bioactive Profiles, Protective Effects, Antioxidant Potentials and Antimicrobial Activity.亚得里亚海沿海地区植物提取物在创新食品和包装应用中的特性：对生物活性特征、保护作用、抗氧化潜力和抗菌活性的见解。
Antioxidants (Basel). 2025 Jul 24;14(8):906. doi: 10.3390/antiox14080906.
9
Phytochemical and Antioxidant Profile of Pitaya (Hylocereus hybridum) Fruits: Elucidation Through Chemical Fractionation.火龙果（Hylocereus hybridum）果实的植物化学成分及抗氧化特性：通过化学分级法进行阐释
J Food Sci. 2025 Aug;90(8):e70502. doi: 10.1111/1750-3841.70502.
10
Multi-omics combining bioinformatic network with kidney-entry constituents revealed the bioactive components and potential mechanisms of Zhijun Tangshen decoction against diabetic nephropathy.多组学结合生物信息网络与入肾成分揭示了志军糖肾方抗糖尿病肾病的生物活性成分及潜在机制。
J Ethnopharmacol. 2025 Aug 18;353(Pt B):120436. doi: 10.1016/j.jep.2025.120436.

本文引用的文献

1
Metabolomics combined with network pharmacology reveals the effects of ripening stages and edible parts on bioactive ingredients of Luohan Guo (Siraitia grosvenorii).代谢组学结合网络药理学揭示罗汉果成熟阶段和可食部分对其生物活性成分的影响。
Food Res Int. 2025 Feb;203:115896. doi: 10.1016/j.foodres.2025.115896. Epub 2025 Jan 31.
2
Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases.解析AMPK-SIRT1-FOXO信号通路：氧化应激诱导疾病的深入分析与突破前景
Antioxidants (Basel). 2025 Jan 9;14(1):70. doi: 10.3390/antiox14010070.
3
Coffee and Cocoa By-Products as Valuable Sources of Bioactive Compounds: The Influence of Ethanol on Extraction.
咖啡和可可副产品作为生物活性化合物的宝贵来源：乙醇对提取的影响。
Antioxidants (Basel). 2025 Jan 1;14(1):42. doi: 10.3390/antiox14010042.
4
Analysis of essential oil composition and assessing the antibacterial and antioxidant properties of the ethanol extract.精油成分分析及乙醇提取物抗菌和抗氧化性能评估。
Heliyon. 2024 Sep 24;10(21):e38389. doi: 10.1016/j.heliyon.2024.e38389. eCollection 2024 Nov 15.
5
Oudemansiella radicata polysaccharides alleviated LPS-induced liver damage via regulating TLR4/NF-κB and Bax/Bcl-2 signaling pathways.长根奥德蘑多糖通过调节TLR4/NF-κB和Bax/Bcl-2信号通路减轻脂多糖诱导的肝损伤。
Int J Biol Macromol. 2024 Dec;282(Pt 6):137370. doi: 10.1016/j.ijbiomac.2024.137370. Epub 2024 Nov 7.
6
The Influence of Solvent Choice on the Extraction of Bioactive Compounds from Asteraceae: A Comparative Review.溶剂选择对菊科植物生物活性成分提取的影响：比较综述
Foods. 2024 Oct 2;13(19):3151. doi: 10.3390/foods13193151.
7
Highly selective separation and purification of lincomycin by macroporous adsorption resin column chromatography.大孔吸附树脂柱层析法对林可霉素的高选择性分离与纯化。
J Chromatogr A. 2024 Oct 25;1735:465282. doi: 10.1016/j.chroma.2024.465282. Epub 2024 Aug 17.
8
Macroporous polymeric resin for the purification of flavonoids from medicinal plants: A review.大孔聚合物树脂在植物药中黄酮类化合物的纯化：综述。
J Sep Sci. 2024 Aug;47(15):e2400372. doi: 10.1002/jssc.202400372.
9
Cardiovascular protective effects of cinnamic acid as a natural phenolic acid: a review.肉桂酸作为一种天然酚酸的心血管保护作用：综述
Arch Physiol Biochem. 2025 Feb;131(1):52-62. doi: 10.1080/13813455.2024.2387694. Epub 2024 Aug 5.
10
The relationship between polysaccharide structure and its antioxidant activity needs to be systematically elucidated.多糖结构与其抗氧化活性之间的关系需要系统地阐明。
Int J Biol Macromol. 2024 Jun;270(Pt 2):132391. doi: 10.1016/j.ijbiomac.2024.132391. Epub 2024 May 17.