Nowak-Wegrzyn Anna, Sicherer Scott H, Akin Cem, Anvari Sara, Bartnikas Lisa M, Berin M Cecilia, Bingemann Theresa A, Boyd Scott, Brown-Whitehorn Terri, Bunyavanich Supinda, Cianferoni Antonella, du Toit George, Fortunato John E, Goldsmith Jeffrey D, Groetch Marion, Leonard Stephanie A, Rao Meenakshi, Schultz Fallon, Schwaninger Julie M, Venter Carina, Westcott-Chavez Amity, Wood Robert A, Togias Alkis
Department of Pediatrics, Hassenfeld Children's Hospital, NYU Grossman School of Medicine, New York, and the Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland; Department of Pediatrics, Division of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Pediatrics, Division of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
J Allergy Clin Immunol. 2025 Feb;155(2):336-356. doi: 10.1016/j.jaci.2024.10.022. Epub 2024 Nov 7.
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food allergy characterized by delayed, protracted vomiting and accompanied by lethargy and pallor, usually 1 to 4 hours after ingesting the food allergen. The pathophysiology of FPIES remains unknown, and currently there are no diagnostic biomarkers available to assess disease activity or its resolution. Over the last 2 decades, FPIES has become increasingly recognized in both pediatric and adult patients. Forty years after the initial FPIES description, the first FPIES code appeared in the International Classification of Diseases, Tenth Revision (ICD-10), and the first international consensus guidelines for the diagnosis and management of FPIES were published. On June 22, 2022, the National Institute of Allergy and Infectious Diseases (NIAID) held its first virtual multidisciplinary workshop on FPIES. Various clinical and translational aspects of FPIES as well as important areas of unmet needs were discussed as priorities for future research during this 2-day virtual workshop. Our report provides a summary of content of the workshop, including updated literature on the topic areas, and also provides critical commentary on the state of FPIES.
食物蛋白诱导的小肠结肠炎综合征（FPIES）是一种非IgE介导的胃肠道食物过敏，其特征为延迟性、持续性呕吐，并伴有嗜睡和面色苍白，通常在摄入食物过敏原后1至4小时出现。FPIES的病理生理学尚不清楚，目前尚无用于评估疾病活动或缓解情况的诊断生物标志物。在过去20年中，FPIES在儿科和成人患者中越来越受到认可。在首次描述FPIES 40年后，首个FPIES编码出现在《国际疾病分类》第十版（ICD-10）中，并且发布了首个FPIES诊断和管理的国际共识指南。2022年6月22日，美国国立过敏和传染病研究所（NIAID）举办了首次关于FPIES的虚拟多学科研讨会。在这个为期两天的虚拟研讨会上，FPIES的各种临床和转化方面以及未满足需求的重要领域被作为未来研究的重点进行了讨论。我们的报告总结了研讨会的内容，包括该主题领域的最新文献，并且还对FPIES的现状提供了批判性评论。
