可乐定及一种新型相关咪唑啉衍生物（替扎尼定）对大鼠胃黏膜的影响。
Influence of clonidine and a new related imidazoline derivative (tizanidine) on rat gastric mucosa.
作者信息
Maeda-Hagiwara M, Watanabe H, Kanaoka R, Watanabe K
出版信息
Pharmacology. 1986;32(2):109-13. doi: 10.1159/000138158.
The effects of a novel imidazoline derivative (tizanidine) on experimental ulcers and glycoproteins in the gastric mucosa and juice of rats were examined and compared with that of clonidine. Tizanidine and clonidine inhibited indomethacin ulcer and aspirin ulcers. Tizanidine, however, did not influence stress ulcer while clonidine showed an inhibitory effect. Although tizanidine and clonidine did not increase glycoproteins in the gastric mucosa, they prevented aspirin-induced changes of glycoproteins in the gastric mucosa and juice, as well as aspirin-induced gastric ulcers. The results suggest that, as with clonidine, tizanidine inhibits drug-induced gastric ulcers and that tizanidine-mediated gastric mucosal protection may prevent gastric ulcers induced by anti-inflammatory agents.
研究了一种新型咪唑啉衍生物（替扎尼定）对大鼠实验性溃疡以及胃黏膜和胃液中糖蛋白的影响，并与可乐定进行了比较。替扎尼定和可乐定均能抑制吲哚美辛溃疡和阿司匹林溃疡。然而，替扎尼定对应激性溃疡无影响，而可乐定有抑制作用。虽然替扎尼定和可乐定不会增加胃黏膜中的糖蛋白，但它们可防止阿司匹林引起的胃黏膜和胃液中糖蛋白的变化以及阿司匹林诱导的胃溃疡。结果表明，与可乐定一样，替扎尼定可抑制药物诱导的胃溃疡，且替扎尼定介导的胃黏膜保护作用可能预防抗炎药诱发的胃溃疡。
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