Hagiwara M, Watanabe H, Kanaoka R
J Pharmacobiodyn. 1985 Oct;8(10):864-7. doi: 10.1248/bpb1978.8.864.
Effects of intracerebroventricular injection of bombesin on gastric mucosal glycoproteins and acid secretion were studied to clarify its action mechanism for experimental ulcers in rats. Bombesin (10 micrograms) prevented stress ulcers and indomethacin ulcers. Aspirin (300 mg/kg p.o.) reduced the high molecular weight glycoproteins extracted from the gastric mucosa, and increased the degraded glycoproteins extracted from gastric juice in pylorus-ligated rats. Bombesin inhibited the aspirin-induced changes of the glycoproteins. Bombesin also inhibited basal gastric acid secretion. These results support the hypothesis that bombesin may affect the central nervous system's control of both gastric defensive and aggressive factors, which contributes to its antiulcerogenic action.
为阐明蛙皮素对大鼠实验性溃疡的作用机制，研究了脑室内注射蛙皮素对胃黏膜糖蛋白和胃酸分泌的影响。蛙皮素（10微克）可预防应激性溃疡和吲哚美辛性溃疡。阿司匹林（300毫克/千克，口服）可降低幽门结扎大鼠胃黏膜中提取的高分子量糖蛋白，并增加胃液中提取的降解糖蛋白。蛙皮素可抑制阿司匹林诱导的糖蛋白变化。蛙皮素还可抑制基础胃酸分泌。这些结果支持以下假说：蛙皮素可能影响中枢神经系统对胃防御和攻击因子的控制，这有助于其抗溃疡作用。
