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健康人体钾动力学模型。

A model for the kinetics of potassium in healthy humans.

作者信息

Leggett R W, Williams L R

出版信息

Phys Med Biol. 1986 Jan;31(1):23-42. doi: 10.1088/0031-9155/31/1/003.

Abstract

A model is developed to describe the distribution and excretion of potassium at arbitrary times during or after intake by ingestion or injection. The movement of K is tracked in greater detail than in previous models and is described in terms of anatomical compartments rather than the hypothetical, mathematically derived pools often considered. Parameter values are derived for a typical resting healthy adult male. Because of its anatomically realistic framework, the model may be used as a point of departure for modelling the behaviour of K in various subgroups of the population under less ideal conditions.

摘要

开发了一个模型来描述通过摄入或注射摄取钾期间或之后任意时间的钾分布和排泄情况。与之前的模型相比,对钾的移动进行了更详细的追踪,并且是根据解剖学隔室来描述的,而不是通常考虑的假设性、数学推导的库。得出了典型静息健康成年男性的参数值。由于其解剖学上现实的框架,该模型可作为在不太理想条件下对不同人群亚组中钾行为进行建模的出发点。

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