Wastney M E, Henkin R I
Georgetown University Medical Center, Washington, DC 20007.
Prog Food Nutr Sci. 1988;12(3):243-54.
A model has been developed to describe zinc metabolism in humans. The model was developed from a series of studies in normal volunteers and patients with various clinical disorders. Zinc metabolism was studied with radiotracers for 9-12 mo before and after a daily oral zinc load of 100 mg. Data were analysed by compartmental analysis and a model was developed that consists of compartments for zinc in the gut, plasma, red blood cells, liver, muscle, bone and other tissues with excretion via urine and feces. Using the model parameters of zinc metabolism including absorption, tissue exchange, secretion and excretion have been determined, together with mass of zinc in tissues and in the whole body. The model has been used to identify five sites of long-term regulation of zinc metabolism in humans. These sites are absorption, excretion, exchange with red blood cells, release of zinc from muscle and secretion of zinc into gut. The model is currently being applied to several areas of nutrition including the effects of dietary fiber on zinc stores, the effects of aging on zinc metabolism and the zinc requirements of neonates.
已开发出一个模型来描述人体锌代谢。该模型是基于对正常志愿者和患有各种临床疾病患者的一系列研究而建立的。在每日口服100毫克锌负荷前后，用放射性示踪剂对锌代谢进行了9至12个月的研究。通过房室分析对数据进行分析，并建立了一个模型，该模型包括肠道、血浆、红细胞、肝脏、肌肉、骨骼和其他组织中锌的房室，通过尿液和粪便排泄。利用该模型确定了锌代谢的参数，包括吸收、组织交换、分泌和排泄，以及组织和全身锌的质量。该模型已被用于确定人体锌代谢长期调节的五个部位。这些部位是吸收、排泄、与红细胞的交换、肌肉中锌的释放以及锌向肠道的分泌。该模型目前正应用于几个营养领域，包括膳食纤维对锌储存的影响、衰老对锌代谢的影响以及新生儿的锌需求。
