Zhang Na, Yang Yuanxin, Xu Daichao
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China.
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China; Shanghai Key Laboratory of Aging Studies, Shanghai, 201210, China.
Trends Cell Biol. 2024 Nov 8. doi: 10.1016/j.tcb.2024.10.005.
Pyroptosis is a lytic, proinflammatory type of programmed cell death crucial for the immune response to pathogen infections and internal danger signals. Gasdermin D (GSDMD) acts as the pore-forming protein in pyroptosis following inflammasome activation. While recent research has improved our understanding of pyroptosis activation and execution, many aspects regarding the molecular mechanisms controlling inflammasome and GSDMD activation remain to be elucidated. A growing body of literature has shown that S-palmitoylation, a reversible post-translational modification (PTM) that attaches palmitate to cysteine residues, contributes to multi-layered regulation of pyroptosis. This review summarizes the emerging roles of S-palmitoylation in pyroptosis research with a focus on mechanisms that regulate NLRP3 inflammasome and GSDMD activation.
细胞焦亡是一种溶解性、促炎性的程序性细胞死亡，对病原体感染和内部危险信号的免疫反应至关重要。在炎性小体激活后，gasdermin D（GSDMD）作为细胞焦亡中形成孔道的蛋白质发挥作用。虽然最近的研究增进了我们对细胞焦亡激活和执行的理解，但关于控制炎性小体和GSDMD激活的分子机制的许多方面仍有待阐明。越来越多的文献表明，S-棕榈酰化是一种将棕榈酸酯附着于半胱氨酸残基的可逆翻译后修饰（PTM），有助于对细胞焦亡进行多层次调节。本综述总结了S-棕榈酰化在细胞焦亡研究中的新作用，重点关注调节NLRP3炎性小体和GSDMD激活的机制。
