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长时间步行对2型糖尿病患者空腹血糖的影响:一项随机对照交叉研究。

The impact of prolonged walking on fasting plasma glucose in type 2 diabetes: A randomised controlled crossover study.

作者信息

Niwaha Anxious J, Shields Beverley M, Rodgers Lauren R, Hattersley Andrew T, Andrews Robert C, Nyirenda Moffat J, Jones Angus G

机构信息

Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, Exeter, UK.

Medical Research Council/Uganda Virus Research Institute and LSHTM Uganda Research Unit, Entebbe, Uganda.

出版信息

Diabet Med. 2025 Mar;42(3):e15468. doi: 10.1111/dme.15468. Epub 2024 Nov 9.

Abstract

AIMS

In many low-income countries, fasting glucose is the primary measure for monitoring glycaemic control. Many patients in these countries walk long distances to the clinic, but the impact of walking on fasting glucose in type 2 diabetes is unknown. We aimed to determine the impact of walking on fasting glucose in people with type 2 diabetes.

METHODS

In a randomised crossover trial, the change in glucose from baseline in the fasting state was compared between walking on a treadmill at a predetermined speed of 4.5 km/h for 1 h and not walking (resting) in people with type 2 diabetes.

RESULTS

In all, 45 participants were enrolled and all completed both visits; 21/45 (46.7%) were women, and the median age was 51. Glucose during and after walking was similar to glucose while at rest; the glucose difference (walking minus rest) was -0.15 (95% CI: -0.55, 0.26) and -0.10 (95% CI: -0.50, 0.31) mmol/L at 1 and 2 h, respectively, p > 0.4 for both.

CONCLUSIONS

Fasting plasma glucose is not meaningfully affected by prolonged walking in participants with type 2 diabetes; therefore, the reliability of fasting glucose for monitoring glycaemic burden is unlikely to be altered in patients who walk to the clinic.

摘要

目的

在许多低收入国家,空腹血糖是监测血糖控制的主要指标。这些国家的许多患者要长途跋涉前往诊所,但步行对2型糖尿病患者空腹血糖的影响尚不清楚。我们旨在确定步行对2型糖尿病患者空腹血糖的影响。

方法

在一项随机交叉试验中,比较了2型糖尿病患者以预定速度4.5公里/小时在跑步机上步行1小时与不步行(休息)时空腹状态下血糖相对于基线的变化。

结果

共招募了45名参与者,所有参与者均完成了两次就诊;其中21/45(46.7%)为女性,中位年龄为51岁。步行期间及之后的血糖与休息时的血糖相似;步行1小时和2小时时的血糖差值(步行减去休息)分别为-0.15(95%CI:-0.55,0.26)和-0.10(95%CI:-0.50,0.31)mmol/L,两者p均>0.4。

结论

2型糖尿病患者长时间步行对空腹血糖无显著影响;因此,对于步行前往诊所的患者,空腹血糖用于监测血糖负担的可靠性不太可能改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a0/11823290/db52a30a5550/DME-42-e15468-g003.jpg

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