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肠道睾酮降解菌和 3/17β-HSD 在雄性睾酮缺乏诱导的高血脂发病机制中的作用。

Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males.

机构信息

Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.

出版信息

NPJ Biofilms Microbiomes. 2024 Nov 9;10(1):123. doi: 10.1038/s41522-024-00599-1.

DOI:10.1038/s41522-024-00599-1
PMID:39521773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11550401/
Abstract

Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P. nitroreducens in mice led to testosterone deficiency and elevated blood lipid levels. Whole-genome sequencing of P. nitroreducens revealed the presence of 3/17β-hydroxysteroid dehydrogenase (3/17β-HSD), a gene responsible for testosterone degradation, which is also associated with hyperlipidemia. Microbiota analysis of fecal samples collected from 158 patients with hyperlipidemia and 151 controls revealed that the relative abundance of P. nitroreducens and 3/17β-HSD in the fecal samples of patients with hyperlipidemia was significantly higher than that in controls. These results suggest that P. nitroreducens and 3/17β-HSD may be related to the onset of testosterone deficiency-induced hyperlipidemia. Therefore, treatments targeted at eradicating testosterone-degrading bacteria are a potential future option for patients with testosterone-induced hyperlipidemia and should thus be studied further.

摘要

睾酮缺乏可导致男性脂质代谢异常，引起高脂血症。我们从男性高脂血症患者的粪便样本中鉴定出了能够降解睾酮的假单胞菌。将这种假单胞菌经胃部给药到小鼠体内，会导致睾酮缺乏和血脂水平升高。对该假单胞菌的全基因组测序揭示了其存在 3/17β-羟甾脱氢酶（3/17β-HSD），这是一种负责睾酮降解的基因，也与高脂血症有关。对从 158 名高脂血症患者和 151 名对照者采集的粪便样本进行的微生物组分析显示，患者粪便样本中假单胞菌和 3/17β-HSD 的相对丰度明显高于对照组。这些结果表明，假单胞菌和 3/17β-HSD 可能与睾酮缺乏诱导的高脂血症的发生有关。因此，针对消除降解睾酮细菌的治疗方法可能是治疗由睾酮引起的高脂血症患者的一种潜在选择，因此值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/28104e75d066/41522_2024_599_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/282c7f1513d5/41522_2024_599_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/1c89d1e552ac/41522_2024_599_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/1d47cd9c6432/41522_2024_599_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/380355bc2569/41522_2024_599_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/569b62d363ad/41522_2024_599_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/28104e75d066/41522_2024_599_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/282c7f1513d5/41522_2024_599_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/1c89d1e552ac/41522_2024_599_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/1d47cd9c6432/41522_2024_599_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/380355bc2569/41522_2024_599_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/569b62d363ad/41522_2024_599_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4550/11550401/28104e75d066/41522_2024_599_Fig6_HTML.jpg

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