Vasudev R, Gentil C G, Covian M R
Physiol Behav. 1986 Jan;36(1):33-9. doi: 10.1016/0031-9384(86)90069-7.
The present study examined the effects of carbachol and angiotensin II injected into the medial and lateral septal areas (MSA and LSA) on the ingestion of primary taste solutions in a free-choice situation. The injection of carbachol or angiotensin II into MSA and LSA of water sated rats evoked a preference for the sweet tasting saccharin solution and water. The lateral septal rats also preferred acetic acid solution. Only the total fluid intake differed significantly among the four groups. In the water deprived rats injection of chemical to the respective groups induced the ingestion of NaCl solution. The MSA rats on injection of carbachol also preferred saccharin apart from NaCl. There was a significant difference in the NaCl intake among the four groups. The quinine solution was not consumed by all the groups. These results indicate that both the carbachol and angiotensin II induce the ingestion of saccharin, NaCl and water. The MSA might be more sensitive in inducing NaCl intake as compared with LSA during deprivation schedule and cholinergic stimulation. The LSA also evokes a preference for the sour tasting acetic acid. Furthermore, the data also suggest that the neurons sensitive to angiotensin are more potent than cholinergic neurons of LSA in producing salt preference.
本研究检测了向内侧和外侧隔区（MSA和LSA）注射卡巴胆碱和血管紧张素II对自由选择情况下原发性味觉溶液摄取的影响。向水饱足大鼠的MSA和LSA注射卡巴胆碱或血管紧张素II会引起对甜味糖精溶液和水的偏好。外侧隔区的大鼠也偏好醋酸溶液。四组之间仅总液体摄入量存在显著差异。在缺水大鼠中，向相应组注射化学物质会促使其摄取NaCl溶液。注射卡巴胆碱的MSA大鼠除了摄取NaCl外还偏好糖精。四组之间NaCl摄入量存在显著差异。并非所有组都饮用奎宁溶液。这些结果表明，卡巴胆碱和血管紧张素II均可促使摄取糖精、NaCl和水。在剥夺期和胆碱能刺激期间，与LSA相比，MSA在促使摄取NaCl方面可能更敏感。LSA也会引起对酸味醋酸的偏好。此外，数据还表明，对血管紧张素敏感的神经元在产生盐偏好方面比LSA的胆碱能神经元更有效。
