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通过将 16-甲基十七烷酸与受损头发进行生物共轭，实现仿生学，从而恢复头发屏障。

Biomimetics through bioconjugation of 16-methylheptadecanoic acid to damaged hair for hair barrier recovery.

机构信息

LG Household and Health Care, Gangseo-gu, Seoul, 07795, Republic of Korea.

出版信息

Sci Rep. 2024 Nov 9;14(1):27387. doi: 10.1038/s41598-024-78770-z.

DOI:10.1038/s41598-024-78770-z
PMID:39521885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11550837/
Abstract

The primary component of the lipid barrier on human hair, which is essential for defense against aging and environmental stresses, is 18-methyleicosanoic acid (18-MEA), which provides hydrophobic properties and protective benefits. Since 18-MEA cannot be regenerated once damaged, developing technology that can permanently bind alternative materials to hair is critical. Once 18-MEA was removed from hair via X-ray photoelectron spectroscopy (XPS), pentaerythritol tetraisoosterate (PTIS) was hydrolyzed and observed via gas chromatography/mass spectrometry (GC/MS) to confirm that it mimicked 18-MEA, and 16-methylheptadecanoic acid (16-MHA) was obtained at pH 4 or lower. 16-MHA was bioconjugated to damaged hair from which 18-MEA was removed via a carbodiimide reaction using polycarbodiimide. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) confirmed that 16-MHA remained on the surface of the bioconjugated hair even after washing. Observation of the endothermic reaction of moisture in hair via a differential scanning calorimetry (DSC) and evaluation of the moisture content confirmed that the physical properties of hair enriched with 16-MHA were similar to those of virgin hair. This biomimetic approach has been shown to restore both external structural integrity and internal moisture homeostasis.

摘要

头发脂质屏障的主要成分是 18-甲基二十烷酸（18-MEA），它对抵御衰老和环境压力至关重要，为头发提供疏水性和保护作用。由于 18-MEA 一旦受损就无法再生，因此开发能够将替代材料永久结合到头发上的技术至关重要。通过 X 射线光电子能谱（XPS）从头发中去除 18-MEA 后，通过气相色谱/质谱（GC/MS）水解并观察到五倍子醇四异硬脂酸酯（PTIS），以确认它模拟了 18-MEA，并在 pH 值为 4 或更低时得到 16-甲基十七烷酸（16-MHA）。16-MHA 通过碳二亚胺反应与从头发中去除 18-MEA 的受损头发进行生物共轭，该反应使用聚碳二亚胺。飞行时间二次离子质谱（TOF-SIMS）证实，即使在洗涤后，16-MHA 仍留在生物共轭头发的表面上。通过差示扫描量热法（DSC）观察头发中水分的吸热反应并评估水分含量，证实富含 16-MHA 的头发的物理性质与 virgin 头发相似。这种仿生方法已被证明可以恢复头发的外部结构完整性和内部水分平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/c40197c0be7f/41598_2024_78770_Fig8_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/7233e3033d54/41598_2024_78770_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/4fd5f02f4537/41598_2024_78770_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/5743df72a6fa/41598_2024_78770_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/c40197c0be7f/41598_2024_78770_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/0cacb4f39686/41598_2024_78770_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/51c030549938/41598_2024_78770_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/505b107d0b9b/41598_2024_78770_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/3fea0d90756b/41598_2024_78770_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/7233e3033d54/41598_2024_78770_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/4fd5f02f4537/41598_2024_78770_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/5743df72a6fa/41598_2024_78770_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4db/11550837/c40197c0be7f/41598_2024_78770_Fig8_HTML.jpg

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本文引用的文献

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Improving the Mechanical Properties of Damaged Hair Using Low-Molecular Weight Hyaluronate.利用低分子量透明质酸改善受损头发的机械性能。
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Insights into the structure of covalently bound fatty acid monolayers on a simplified model of the hair epicuticle from molecular dynamics simulations.从分子动力学模拟看发角质层简化模型中脂肪酸单层的共价结合结构。
Langmuir. 2012 Sep 11;28(36):13008-17. doi: 10.1021/la302161x. Epub 2012 Aug 27.