Durgin Joseph S, Wong Sunny Y
Department of Dermatology, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
EMBO Mol Med. 2024 Dec;16(12):3027-3029. doi: 10.1038/s44321-024-00170-7. Epub 2024 Nov 9.
The hair follicle is thought to be a site of ‘immune privilege,’ or relative protection from autoimmune and inflammatory responses. In particular, the long-lived, quiescent hair follicle stem cells (HFSCs) are strikingly resistant to cytotoxic immune effectors such as T cells and natural killer (NK) cells, even in systems where these cells are artificially directed to attack HFSCs. Nonetheless, many forms of alopecia are associated with immune-mediated damage of the hair follicle epithelium, suggesting a failure of immune privilege. What precipitates the collapse of HFSC immune privilege in alopecia? In this current issue of , Strobl et al use an innovative mouse model to add to our mechanistic understanding of this disorder (Strobl et al, 2024).
毛囊被认为是一个具有“免疫特权”的部位，即相对免受自身免疫和炎症反应影响的部位。特别是，长寿、静止的毛囊干细胞（HFSCs）对细胞毒性免疫效应细胞如T细胞和自然杀伤（NK）细胞具有显著抗性，即使在这些细胞被人为引导攻击HFSCs的系统中也是如此。然而，许多形式的脱发都与毛囊上皮的免疫介导损伤有关，这表明免疫特权失效。在脱发中，是什么导致了HFSC免疫特权的崩溃？在本期杂志中，斯特罗布尔等人使用一种创新的小鼠模型，增进了我们对这种疾病发病机制的理解（斯特罗布尔等人，2024年）。
