免疫浸润与原发性雌激素受体阳性浸润性小叶乳腺癌的转录组亚型相关。
Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer.
作者信息
Chen Fangyuan, Onkar Sayali, Zou Jian, Li Yujia, Arbore Haley, Maley Sai, Tseng George, Lucas Peter C, Bruno Tullia C, Vignali Dario A A, Foldi Julia, Balic Marija, Lee Adrian V, Oesterreich Steffi
机构信息
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
NPJ Precis Oncol. 2024 Nov 9;8(1):257. doi: 10.1038/s41698-024-00746-z.
Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer. Our work identified genes related to ILC immune microenvironment and prognosis.
了解乳腺癌与微环境之间的相互作用至关重要。在此，我们通过对21例雌激素受体阳性/人表皮生长因子受体2阴性的小叶原位癌进行RNA测序和多重免疫组化，确定了两种转录组亚型和五种免疫浸润模式。我们发现增殖性亚型与抑制性免疫浸润增加相关，并定义了一种与较低增殖性、促炎性肿瘤相关巨噬细胞浸润以及雌激素受体阳性乳腺癌患者生存率提高相关的特征。我们的研究确定了与小叶原位癌免疫微环境和预后相关的基因。
Zotero 插件