Saadh Mohamed J, Mustafa Mohammed Ahmed, Malathi H, Ahluwalia Gunveen, Kaur Sumeet, Al-Dulaimi Mohammad Abd Alrazaq Hameed, Alubiady Mahmood Hasen Shuhata, Zain Al-Abdeen Salah Hassan, Shakier Hussein Ghafel, Ali Mohammed Shnain, Ahmad Irfan, Abosaoda Munther Kadhim
Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Department of Medical Laboratory Technology, University of Imam Jaafar AL-Sadiq, Baghdad, Iraq.
Med Oncol. 2024 Jul 13;41(8):201. doi: 10.1007/s12032-024-02443-0.
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different cells and proteins, plays a crucial role in tumor growth and chemoresistance. Targeting tumor stroma, consisting of diverse non-tumor cells such as fibroblasts, extracellular matrix (ECM), immune cells, and also pre-vascular cells is encouraging for remodeling solid cancers, such as pancreatic cancer. Remodeling the stroma of pancreas tumors can be suggested as a strategy for reducing resistance to chemo/immunotherapy. Several studies have shown that phytochemicals from plants can affect the tumor environment and have anti-cancer properties. By targeting key pathways involved in stromal activation, phytochemicals may disrupt communication between the tumor and stroma and make tumor cells more sensitive to different treatments. Additionally, phytochemicals have immunomodulatory and anti-angiogenic properties, all of which contribute to their potential in treating pancreatic cancer. This review will provide a detailed look at how phytochemicals impact the tumor stroma and their effects on pancreatic tumor growth, spread, and response to treatment. It will also explore the potential of combining phytochemicals with other treatment options like chemotherapy, immunotherapy, and radiation.
胰腺癌仍然是一个严重的健康问题，治疗选择有限。肿瘤基质是一个由不同细胞和蛋白质组成的复杂环境，在肿瘤生长和化疗耐药性中起着关键作用。靶向肿瘤基质，其由多种非肿瘤细胞组成，如成纤维细胞、细胞外基质（ECM）、免疫细胞以及血管前体细胞，对于重塑实体癌（如胰腺癌）具有积极意义。重塑胰腺肿瘤的基质可被视为一种降低对化疗/免疫治疗耐药性的策略。多项研究表明，植物中的植物化学物质可影响肿瘤微环境并具有抗癌特性。通过靶向参与基质激活的关键通路，植物化学物质可能会破坏肿瘤与基质之间的通讯，使肿瘤细胞对不同治疗更敏感。此外，植物化学物质具有免疫调节和抗血管生成特性，所有这些都有助于其在治疗胰腺癌方面的潜力。本综述将详细探讨植物化学物质如何影响肿瘤基质及其对胰腺肿瘤生长、扩散和治疗反应的影响。它还将探索将植物化学物质与化疗、免疫治疗和放疗等其他治疗选择相结合的潜力。
