Delgersaikhan Nyamsurendejid, Odkhuu Erdenezaya, Khaltar Purevsuren, Samdan Enkhbaatar, Dugarsuren Uranchimeg, Dalkhsuren Shine-Od, Dorjkhuu Amgalanbaatar, Aldartsogt Dolgorsuren, Amgalanbaatar Avirmed
Department of Anatomy, 106188 School of Bio-Medicine, Mongolian National University of Medical Sciences , Ulaanbaatar, Mongolia.
J Complement Integr Med. 2024 Nov 11;21(4):472-480. doi: 10.1515/jcim-2024-0316. eCollection 2024 Dec 1.
The is a medicinal mushroom that grows on mature birch trees and is commonly used in traditional medicine for various ailments. The current study aimed to explore the hypoglycemic, hypolipidemic, and pancreatic protective effects of the water extract of Mongolian natural on alloxan-induced diabetic mice.
Alloxan monohydrate (200 mg/kg) was intraperitoneally single injected into C57BL/6 mice to induce diabetes. Alloxan-induced diabetic mice were orally given the water extract of inonotus obliquus (WEIO) at doses of 500 mg/kg and subcutaneously administered with insulatard 0.6 IU for 4 weeks. Subsequently, the levels of factors related to blood glucose, insulin and lipids were assessed.
WEIO significantly restored body weight, reduced fasting blood glucose levels, improved glucose tolerance ability, and increased insulin levels compared to the control diabetic mice. WEIO also enhanced cholesterol transportation in the liver, correlated with increased HDL-C levels and decreased TC, TG and LDL-C levels. Histologic examinations revealed that WEIO alleviated alloxan-induced pancreatic tissue damage.
Natural Mongolian I. Obliquus water extracts have an antihyperglycemic effect and enhance islet cell function in alloxan-induced diabetic mice. It is a good candidate for a hypoglycemic functional food or medicine.
桦褐孔菌是一种生长在成熟桦树上的药用蘑菇，在传统医学中常用于治疗各种疾病。本研究旨在探讨蒙古天然桦褐孔菌水提取物对四氧嘧啶诱导的糖尿病小鼠的降血糖、降血脂及胰腺保护作用。
将一水合四氧嘧啶（200mg/kg）腹腔单次注射到C57BL/6小鼠体内诱导糖尿病。给四氧嘧啶诱导的糖尿病小鼠口服500mg/kg剂量的桦褐孔菌水提取物（WEIO），并皮下注射0.6IU胰岛素，持续4周。随后，评估与血糖、胰岛素和血脂相关的因子水平。
与对照糖尿病小鼠相比，WEIO显著恢复体重，降低空腹血糖水平，提高葡萄糖耐量能力，并增加胰岛素水平。WEIO还增强了肝脏中的胆固醇转运，这与HDL-C水平升高以及TC、TG和LDL-C水平降低相关。组织学检查显示，WEIO减轻了四氧嘧啶诱导的胰腺组织损伤。
天然蒙古桦褐孔菌水提取物对四氧嘧啶诱导的糖尿病小鼠具有降血糖作用，并增强胰岛细胞功能。它是一种很好的降血糖功能性食品或药物候选物。
