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基于野外研究获得的民族药理学信息对传统草药的植物化学研究。

Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies.

机构信息

Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.

出版信息

J Nat Med. 2021 Sep;75(4):762-783. doi: 10.1007/s11418-021-01545-7. Epub 2021 Jul 13.

DOI:10.1007/s11418-021-01545-7
PMID:34255289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8397699/
Abstract

Traditional herbal medicines, which have been used in the matured traditional medical systems as well as those have been used in ethnic medical systems, are invaluable resources of drug seeds. Ethnobotanical and ethnopharmacological survey may provide useful information of these herbal medicines, which are valuable for searching new bioactive molecules. From this viewpoint, we have been performing the ethnobotanical and ethnopharmacological field studies in Yunnan Province and Guangxi Zhuang Autonomous Region, China, and Mongolia. Phytochemical studies on traditional herbal medicines were performed based on the information obtained by our ethnobotanical survey. Herbal medicines used in Uzbekistan and Bangladesh were also investigated on the basis of the ethnopharmacological information obtained from collaborative researchers in the respective regions. Some studies were carried out for searching active substance(s) based on bioassay-guided fractionation and isolation. Over 150 new molecules were isolated in these studies, and their various biological activities were also demonstrated. This review summarizes the results of phytochemical studies of those traditional herbal medicines as well as biological activities of the isolated molecules.

摘要

传统草药，无论是在成熟的传统医学体系中使用，还是在民族医学体系中使用，都是药物种子的宝贵资源。民族植物学和民族药理学调查可以提供这些草药的有用信息，这些信息对于寻找新的生物活性分子很有价值。从这个角度来看，我们一直在中国云南省和广西壮族自治区以及蒙古进行民族植物学和民族药理学的实地研究。基于我们的民族植物学调查获得的信息，对传统草药进行了植物化学研究。还根据在乌兹别克斯坦和孟加拉国的合作研究人员获得的民族药理学信息，对这些国家使用的草药进行了调查。一些研究是基于基于生物测定指导的分离和分离来寻找活性物质的。在这些研究中分离出了 150 多种新分子，并证明了它们具有各种生物活性。本综述总结了这些传统草药的植物化学研究结果以及分离出的分子的生物活性。

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