• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

转运RNA调控和氨基酸使用偏好反映了一种协调的代谢适应……（原文此处不完整）

tRNA regulation and amino acid usage bias reflect a coordinated metabolic adaptation in .

作者信息

Li Qian, Vetter Leonie, Veith Ylva, Christ Elena, Végvári Ákos, Sahin Cagla, Ribacke Ulf, Wahlgren Mats, Ankarklev Johan, Larsson Ola, Chun-Leung Chan Sherwin

机构信息

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.

出版信息

iScience. 2024 Oct 12;27(11):111167. doi: 10.1016/j.isci.2024.111167. eCollection 2024 Nov 15.

DOI:10.1016/j.isci.2024.111167
PMID:39524331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11544085/
Abstract

An adaptive feature of malaria-causing parasites is the digestion of host hemoglobin (HB) to acquire amino acids (AAs). Here, we describe a link between nutrient availability and translation dependent regulation of gene expression as an adaptive strategy. We show that tRNA expression in does not match the decoding need expected for optimal translation. A subset of tRNAs decoding AAs that are insufficiently provided by HB are lowly expressed, wherein the abundance of a protein-coding transcript is negatively correlated with the decoding requirement of these tRNAs. Proliferation-related genes have evolved a high requirement of these tRNAs, thereby proliferation can be modulated by repressing protein synthesis of these genes during nutrient stress. We conclude that the parasite modulates translation elongation by maintaining a discordant tRNA profile to exploit variations in AA-composition among genes as an adaptation strategy. This study exemplifies metabolic adaptation as an important driving force for protein evolution.

摘要

疟原虫的一个适应性特征是消化宿主血红蛋白（HB）以获取氨基酸（AAs）。在此，我们描述了营养可用性与基因表达的翻译依赖性调控之间的联系，将其作为一种适应性策略。我们表明，疟原虫中的tRNA表达与最佳翻译所需的解码需求不匹配。解码HB提供不足的氨基酸的tRNA子集表达水平较低，其中蛋白质编码转录本的丰度与这些tRNA的解码需求呈负相关。与增殖相关的基因对这些tRNA的需求较高，因此在营养应激期间，可以通过抑制这些基因的蛋白质合成来调节增殖。我们得出结论，疟原虫通过维持不一致的tRNA谱来调节翻译延伸，以利用基因间氨基酸组成的差异作为一种适应策略。这项研究例证了代谢适应是蛋白质进化的重要驱动力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/30867566698d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/b965b2e8ab0c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/72655baa508b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/3a059cfc5bf5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/df248a12a2db/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/6fb4fe67339c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/ddfdaac6ef96/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/30867566698d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/b965b2e8ab0c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/72655baa508b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/3a059cfc5bf5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/df248a12a2db/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/6fb4fe67339c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/ddfdaac6ef96/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a14/11544085/30867566698d/gr6.jpg

相似文献

1
tRNA regulation and amino acid usage bias reflect a coordinated metabolic adaptation in .转运RNA调控和氨基酸使用偏好反映了一种协调的代谢适应……（原文此处不完整）
iScience. 2024 Oct 12;27(11):111167. doi: 10.1016/j.isci.2024.111167. eCollection 2024 Nov 15.
2
Apicomplexa-specific tRip facilitates import of exogenous tRNAs into malaria parasites.顶复门特异性tRip促进外源tRNA导入疟原虫。
Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4717-22. doi: 10.1073/pnas.1600476113. Epub 2016 Apr 11.
3
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区，服用抗叶酸抗疟药物的人群中，叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
4
Aminoacylation of Plasmodium falciparum tRNA(Asn) and insights in the synthesis of asparagine repeats.疟原虫 tRNA(Asn)的氨酰化作用及天冬酰胺重复序列合成的研究进展。
J Biol Chem. 2013 Dec 20;288(51):36361-71. doi: 10.1074/jbc.M113.522896. Epub 2013 Nov 6.
5
Comparative analysis of codon usage patterns of helical interspersed subtelomeric (PHIST) proteins.螺旋散布亚端粒（PHIST）蛋白密码子使用模式的比较分析。
Front Microbiol. 2023 Dec 14;14:1320060. doi: 10.3389/fmicb.2023.1320060. eCollection 2023.
6
Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation.疟原虫寄生虫应激耐受由 DNMT2 介导的 tRNA 胞嘧啶甲基化调控。
mBio. 2021 Dec 21;12(6):e0255821. doi: 10.1128/mBio.02558-21. Epub 2021 Nov 2.
7
Molecular Coping Mechanisms: Reprogramming tRNAs To Regulate Codon-Biased Translation of Stress Response Proteins.分子应对机制：重编程 tRNA 以调控应激反应蛋白的密码子偏爱性翻译。
Acc Chem Res. 2023 Dec 5;56(23):3504-3514. doi: 10.1021/acs.accounts.3c00572. Epub 2023 Nov 22.
8
Genetic and chemical validation of aminopeptidase A-M17 as a drug target in the hemoglobin digestion pathway.遗传和化学验证天冬氨酰蛋白酶 A-M17 作为血红蛋白消化途径中的药物靶点。
Elife. 2022 Sep 13;11:e80813. doi: 10.7554/eLife.80813.
9
Confers Survival upon Amino Acid Starvation.在氨基酸饥饿时赋予细胞存活能力。
mBio. 2017 Mar 28;8(2):e02317-16. doi: 10.1128/mBio.02317-16.
10
tRNAs as a Driving Force of Genome Evolution in Yeast.转运RNA作为酵母基因组进化的驱动力
Front Microbiol. 2021 Mar 11;12:634004. doi: 10.3389/fmicb.2021.634004. eCollection 2021.

引用本文的文献

1
SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.SnoBIRD：一种用于识别C/D盒小核仁RNA并完善其在所有真核生物中的注释的工具。
Nucleic Acids Res. 2025 Jul 19;53(14). doi: 10.1093/nar/gkaf708.

本文引用的文献

1
Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation.疟原虫 DNA 甲基转移酶在转录和翻译调控中的双重作用的表征。
Nucleic Acids Res. 2023 May 8;51(8):3918-3933. doi: 10.1093/nar/gkad248.
2
A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony.恶性疟原虫溶血磷脂酶通过寄生虫脂质储存来调节宿主脂肪酸通量，从而实现受控制的无性裂殖。
Cell Rep. 2023 Apr 25;42(4):112251. doi: 10.1016/j.celrep.2023.112251. Epub 2023 Apr 3.
3
A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency.
非经典感应途径介导疟原虫适应氨基酸缺乏。
Commun Biol. 2023 Feb 21;6(1):205. doi: 10.1038/s42003-023-04566-y.
4
A nascent peptide code for translational control of mRNA stability in human cells.一个新生肽密码，用于控制人类细胞中 mRNA 稳定性的翻译。
Nat Commun. 2022 Nov 11;13(1):6829. doi: 10.1038/s41467-022-34664-0.
5
Kozak Similarity Score Algorithm Identifies Alternative Translation Initiation Codons Implicated in Cancers.Kozak 相似性评分算法鉴定出与癌症相关的替代翻译起始密码子。
Int J Mol Sci. 2022 Sep 12;23(18):10564. doi: 10.3390/ijms231810564.
6
Babesia, Theileria, Plasmodium and Hemoglobin.巴贝斯虫、泰勒虫、疟原虫与血红蛋白。
Microorganisms. 2022 Aug 15;10(8):1651. doi: 10.3390/microorganisms10081651.
7
Dynamic Landscapes of tRNA Transcriptomes and Translatomes in Diverse Mouse Tissues.不同小鼠组织中 tRNA 转录组和翻译组的动态景观。
Genomics Proteomics Bioinformatics. 2023 Aug;21(4):834-849. doi: 10.1016/j.gpb.2022.07.006. Epub 2022 Aug 8.
8
Mechanisms of protein evolution.蛋白质进化的机制。
Protein Sci. 2022 Jul;31(7):e4362. doi: 10.1002/pro.4362.
9
Nutrient Limitation Magnifies Fitness Costs of Antimalarial Drug Resistance Mutations.营养限制放大了抗疟药物耐药突变的适应代价。
Antimicrob Agents Chemother. 2022 May 17;66(5):e0152921. doi: 10.1128/aac.01529-21. Epub 2022 Apr 25.
10
5-methylcytosine modification by NSUN2 stabilizes mRNA and mediates the development of gametocytes.NSUN2 通过 5-甲基胞嘧啶修饰稳定 mRNA，并介导配子体的发育。
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2110713119.