Ruml Angelique, Caceres Ibeth P, Sayyadioskoie Shannon, Patel Jay R, Nawas Zeena
Dermatology, Baylor College of Medicine, Houston, USA.
Cureus. 2024 Oct 7;16(10):e71032. doi: 10.7759/cureus.71032. eCollection 2024 Oct.
The popularity of nonsurgical, minimally invasive cosmetic treatments has increased drastically in recent years, with lip augmentation being one of the most common. Dermatologists play an important role in the delivery of safe, evidence-based options for lip augmentation, including lip filler. Many types of filler are available to patients, and their safety profiles have been studied extensively. Adverse effects, if they do occur, are generally mild and self-limited; however, fewer data exist describing the adverse effects of fillers, particularly hyaluronic acid (HA) dermal fillers, in patients with a history of autoimmune disease. This report presents a case of a granulomatous delayed hypersensitivity reaction to HA filler in a patient with ankylosing spondylitis, which was subsequently successfully treated with hyaluronidase. As complications of cosmetic procedures affect patients' quality of life, this case highlights the importance of recognizing similar reactions to HA filler and the efficacy of hyaluronidase as a treatment option when they occur.
近年来，非手术、微创美容治疗的受欢迎程度急剧上升，丰唇是最常见的治疗之一。皮肤科医生在提供安全、循证的丰唇选择（包括唇部填充剂）方面发挥着重要作用。患者可使用多种类型的填充剂，并且对其安全性进行了广泛研究。如果出现不良反应，通常较为轻微且具有自限性；然而，关于自身免疫性疾病史患者使用填充剂，尤其是透明质酸（HA）真皮填充剂的不良反应的数据较少。本报告介绍了1例强直性脊柱炎患者对HA填充剂发生肉芽肿性迟发型超敏反应的病例，该患者随后成功接受了透明质酸酶治疗。由于美容手术的并发症会影响患者的生活质量，该病例突出了识别对HA填充剂的类似反应的重要性以及透明质酸酶作为治疗选择在这类反应发生时的有效性。
