Weiss Michael A
Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Nat Commun. 2024 Nov 11;15(1):9744. doi: 10.1038/s41467-024-54006-6.
Reporting in , Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.
凯尔森及其同事的报告描述了一种基于A链和B链分离的胰岛素清除氧化还原机制。该研究利用一种免受经典清除途径影响的超长作用类似物，突出了药理学中蛋白质稳定性的原理。
