• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

发热伴血小板减少综合征患者外周免疫的转录组特征

Transcriptome Profiles Characteristics of the Peripheral Immune in Patients with Severe Fever with Thrombocytopenia Syndrome.

作者信息

Zhang Yuwei, Sun Qingshuai, Liu Tao, Chang Caiyun, Chen Xiangjuan, Duan Qing, Wen Zixuan, Zhang Xiaomei, Pang Bo, Jiang Xiaolin

机构信息

Infectious Disease Prevention and Control Section, Shandong Center for Disease Control and Prevention, Jinan, Shandong Province, People's Republic of China.

School of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Province, People's Republic of China.

出版信息

J Inflamm Res. 2024 Nov 7;17:8357-8374. doi: 10.2147/JIR.S485118. eCollection 2024.

DOI:10.2147/JIR.S485118
PMID:39530000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11552436/
Abstract

PURPOSE

Severe fever with thrombocytopenia syndrome (SFTS) is an acute viral infection disease with a high mortality, but there are no specific effective drugs or vaccines available for use. To develop effective treatment methods, more basic researches are urgently needed to elucidate the response mechanisms of patients.

PATIENTS AND METHODS

Here, we conducted the transcriptomic analysis of peripheral immunity in 14 SFTS patients, ranging from moderate infection to severe and fatal disease.

RESULTS

The results showed orderly cytokine signaling pathway modulation in moderate patients, cellular immunosuppression in severe patients, and significant dysregulation of the inflammatory response and coagulation dysfunction characteristic of deceased patients. In addition, WGCNA further showed a significant positive correlation between fatal outcomes and B cell and immunoglobulin mediated immune function modules, as well as a significant negative correlation with coagulation function modules.

CONCLUSION

Overall, our research findings systematically observed potential immune mechanisms underlying clinical symptom heterogeneity and noteworthily revealed multiple signaling pathways leading to coagulation dysfunction in fatal outcomes, not just related to decreased platelet count, which can further elucidate the interaction between viruses and hosts and contribute to clinical treatment.

摘要

目的

发热伴血小板减少综合征（SFTS）是一种急性病毒感染性疾病，死亡率高，但目前尚无特效药物或疫苗可供使用。为开发有效的治疗方法，迫切需要更多基础研究来阐明患者的反应机制。

患者与方法

在此，我们对14例SFTS患者的外周免疫进行了转录组分析，这些患者的病情从中度感染到重度及致命性疾病不等。

结果

结果显示，中度患者的细胞因子信号通路调节有序，重度患者存在细胞免疫抑制，而死亡患者则表现出炎症反应的显著失调和凝血功能障碍。此外，加权基因共表达网络分析（WGCNA）进一步显示，致命结局与B细胞和免疫球蛋白介导的免疫功能模块之间存在显著正相关，与凝血功能模块存在显著负相关。

结论

总体而言，我们的研究结果系统地观察到了临床症状异质性背后的潜在免疫机制，并值得注意地揭示了导致致命结局中凝血功能障碍的多种信号通路，而不仅仅与血小板计数减少有关，这可以进一步阐明病毒与宿主之间的相互作用，并有助于临床治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/65f985a50185/JIR-17-8357-g0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/4a2055457f7e/JIR-17-8357-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/3edbccdc6802/JIR-17-8357-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/dcaeaf3bdc2f/JIR-17-8357-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/2dc2e331a72d/JIR-17-8357-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/716b719f02a3/JIR-17-8357-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/fe5e8a93b0e4/JIR-17-8357-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/049819189315/JIR-17-8357-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/332e90ba6c76/JIR-17-8357-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/566d03b84703/JIR-17-8357-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/39e8c4864b3c/JIR-17-8357-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/425993ce1911/JIR-17-8357-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/86ff910efd6d/JIR-17-8357-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/b014dc0fd560/JIR-17-8357-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/65f985a50185/JIR-17-8357-g0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/4a2055457f7e/JIR-17-8357-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/3edbccdc6802/JIR-17-8357-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/dcaeaf3bdc2f/JIR-17-8357-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/2dc2e331a72d/JIR-17-8357-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/716b719f02a3/JIR-17-8357-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/fe5e8a93b0e4/JIR-17-8357-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/049819189315/JIR-17-8357-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/332e90ba6c76/JIR-17-8357-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/566d03b84703/JIR-17-8357-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/39e8c4864b3c/JIR-17-8357-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/425993ce1911/JIR-17-8357-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/86ff910efd6d/JIR-17-8357-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/b014dc0fd560/JIR-17-8357-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aea/11552436/65f985a50185/JIR-17-8357-g0014.jpg

相似文献

1
Transcriptome Profiles Characteristics of the Peripheral Immune in Patients with Severe Fever with Thrombocytopenia Syndrome.发热伴血小板减少综合征患者外周免疫的转录组特征
J Inflamm Res. 2024 Nov 7;17:8357-8374. doi: 10.2147/JIR.S485118. eCollection 2024.
2
Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia Syndrome.严重发热伴血小板减少综合征患者炎症特征和 B 细胞功能的分子特征。
mBio. 2021 Feb 16;12(1):e02583-20. doi: 10.1128/mBio.02583-20.
3
Nucleocapsid protein-specific IgM antibody responses in the disease progression of severe fever with thrombocytopenia syndrome.严重发热伴血小板减少综合征疾病进展过程中核衣壳蛋白特异性 IgM 抗体反应。
Ticks Tick Borne Dis. 2019 Apr;10(3):639-646. doi: 10.1016/j.ttbdis.2019.02.003. Epub 2019 Feb 7.
4
The clinical and immunological characteristics in fatal severe fever with thrombocytopenia syndrome virus (SFTSV) infection.严重发热伴血小板减少综合征病毒（SFTSV）感染的临床和免疫学特征。
Clin Immunol. 2023 Mar;248:109262. doi: 10.1016/j.clim.2023.109262. Epub 2023 Feb 14.
5
Correlation between thrombocytopenia and host response in severe fever with thrombocytopenia syndrome.严重发热伴血小板减少综合征中血小板减少与宿主反应的相关性。
PLoS Negl Trop Dis. 2020 Oct 29;14(10):e0008801. doi: 10.1371/journal.pntd.0008801. eCollection 2020 Oct.
6
Acute pancreatitis in patients with severe fever with thrombocytopenia syndrome virus infection.严重发热伴血小板减少综合征病毒感染患者的急性胰腺炎。
Pancreatology. 2020 Dec;20(8):1631-1636. doi: 10.1016/j.pan.2020.09.024. Epub 2020 Oct 3.
7
A global lipid map of severe fever with thrombocytopenia syndrome virus infection reveals glycerophospholipids as novel prognosis biomarkers.发热伴血小板减少综合征病毒感染的全球脂质图谱揭示甘油磷脂为新型预后生物标志物。
mBio. 2024 Dec 11;15(12):e0262824. doi: 10.1128/mbio.02628-24. Epub 2024 Nov 13.
8
Lethal severe fever with thrombocytopenia syndrome virus infection causes systemic germinal centre failure and massive T cell apoptosis in cats.致命性严重发热伴血小板减少综合征病毒感染导致猫出现全身性生发中心衰竭和大量T细胞凋亡。
Front Microbiol. 2024 Jan 5;14:1333946. doi: 10.3389/fmicb.2023.1333946. eCollection 2023.
9
[A Fatal Case of Severe Fever with Thrombocytopenia Syndrome Complicated by Hemophagocytic Lymphohistiocytosis].[1例严重发热伴血小板减少综合征合并噬血细胞性淋巴组织细胞增生症致死病例]
Kansenshogaku Zasshi. 2015 Sep;89(5):592-6. doi: 10.11150/kansenshogakuzasshi.89.592.
10
Clinical and Pathological Findings in Fatal Cases of Severe Fever With Thrombocytopenia Syndrome With High Viremia in Cats.猫严重发热伴血小板减少综合征高病毒血症致死病例的临床和病理观察。
Top Companion Anim Med. 2023 Jan-Feb;52:100756. doi: 10.1016/j.tcam.2022.100756. Epub 2022 Dec 28.

本文引用的文献

1
Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and ZF2001 booster vaccine.70岁以上老年人接种第三剂新冠病毒BBIBP-CorV和ZF2001加强疫苗后外周血单个核细胞中的抗体和转录图谱
Immun Ageing. 2024 Jan 27;21(1):11. doi: 10.1186/s12979-023-00408-x.
2
Pathogenicity and landscape of differential gene expression in mice orally infected with clinical coxsackievirus A6 (CA6).临床柯萨奇病毒A6（CA6）经口感染小鼠后的致病性及差异基因表达图谱
J Virol. 2024 Feb 20;98(2):e0135823. doi: 10.1128/jvi.01358-23. Epub 2024 Jan 16.
3
Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner.
以帽状抢夺的方式调控 WNT-CTNNB1 信号通路。
mBio. 2023 Dec 19;14(6):e0168823. doi: 10.1128/mbio.01688-23. Epub 2023 Oct 26.
4
Fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) and severe and critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-β.严重发热伴血小板减少综合征（SFTS）和严重及危重新冠肺炎的致命结局与 IL-10 和 IL-6 的过度产生以及 TGF-β 的产生不足有关。
J Med Virol. 2023 Jul;95(7):e28894. doi: 10.1002/jmv.28894.
5
Transcriptomic Profiling Reveals Intense Host-Pathogen Dispute Compromising Homeostasis during Acute Rift Valley Fever Virus Infection.转录组谱分析揭示了急性裂谷热病毒感染期间强烈的宿主-病原体争议，破坏了体内平衡。
J Virol. 2023 Jun 29;97(6):e0041523. doi: 10.1128/jvi.00415-23. Epub 2023 Jun 12.
6
Screening core genes and signaling pathways after SFTSV infection by integrated transcriptome profiling analysis.整合转录组谱分析筛选发热伴血小板减少综合征病毒感染后的核心基因和信号通路。
Virus Res. 2023 Jul 15;332:199138. doi: 10.1016/j.virusres.2023.199138. Epub 2023 May 23.
7
Severe Fever with Thrombocytopenia Syndrome Virus Infection, Thailand, 2019-2020.2019-2020 年泰国严重发热伴血小板减少综合征病毒感染。
Emerg Infect Dis. 2022 Dec;28(12):2572-2574. doi: 10.3201/eid2812.221183.
8
The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors.无尽的战争：发热伴血小板减少综合征病毒、宿主免疫与遗传因素。
Front Cell Infect Microbiol. 2022 Jun 15;12:808098. doi: 10.3389/fcimb.2022.808098. eCollection 2022.
9
Single-cell landscape of peripheral immune responses to fatal SFTS.外周免疫对致命性发热伴血小板减少综合征病毒反应的单细胞全景图。
Cell Rep. 2021 Nov 23;37(8):110039. doi: 10.1016/j.celrep.2021.110039.
10
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data.clusterProfiler 4.0：用于解释组学数据的通用富集工具。
Innovation (Camb). 2021 Jul 1;2(3):100141. doi: 10.1016/j.xinn.2021.100141. eCollection 2021 Aug 28.