Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clin Immunol. 2023 Mar;248:109262. doi: 10.1016/j.clim.2023.109262. Epub 2023 Feb 14.
This study aimed to make a comprehensive evaluation of peripheral immune profiles for further understanding the immunopathogenesis of severe fever with thrombocytopenia syndrome (SFTS).
Forty-seven patients with SFTS virus infection were included, of which 24 were deceased. The percentages, absolute numbers, phenotype of lymphocyte subsets were detected by flow cytometry.
In patients with SFTS, the numbers of CD3T, CD4T, CD8T and NKT cells were decreased compared with healthy controls (HCs), accompanied with highly active and exhausted phenotypes for T cells, and overproliferating plasmablasts. High inflammatory status, dysregulation of coagulation and host immune response were more obvious in deceased patients than that of survivors. Higher levels of PCT, IL-6, IL-10, TNF-α, APTT, TT and the occurrence of hemophagocytic lymphohistiocytosis were poor prognostic indicators of SFTS.
The evaluation of immunological markers in combination with laboratory tests has critical value for selecting prognostic markers and potential treatment target.
本研究旨在全面评估外周免疫谱，以进一步了解发热伴血小板减少综合征（SFTS）的免疫发病机制。
纳入 47 例 SFTS 病毒感染者，其中 24 例死亡。采用流式细胞术检测淋巴细胞亚群的百分比、绝对数和表型。
与健康对照者（HCs）相比，SFTS 患者的 CD3T、CD4T、CD8T 和 NKT 细胞数量减少，同时 T 细胞表现出高度活跃和耗竭的表型，浆母细胞过度增殖。死亡患者的炎症状态、凝血失调和宿主免疫反应比存活患者更为明显。较高的 PCT、IL-6、IL-10、TNF-α、APTT、TT 水平和噬血细胞性淋巴组织细胞增生症的发生是 SFTS 的不良预后指标。
结合实验室检查评估免疫标志物对选择预后标志物和潜在治疗靶点具有重要价值。
