保留乳头的乳房切除术：年轻患者与老年患者的比较。
Nipple-sparing mastectomy in young versus elderly patients.
机构信息
Hospital Israelita Albert Einstein São PauloSP Brazil Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Universidade Católica do Rio Grande do Sul Porto AlegreRS Brazil Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
Rev Bras Ginecol Obstet. 2024 Oct 23;46. doi: 10.61622/rbgo/2024rbgo90. eCollection 2024.
OBJECTIVE
In this study, we compared indications and outcomes of 115 young (< 40 years) versus 40 elderly (> 60 years) patients undergoing nipple-sparing mastectomy (NSM) as risk-reducing surgery or for breast cancer (BC) treatment.
METHODS
Between January 2004 and December 2018, young and elderly patients undergoing NSM with complete data from at least 6 months of follow-up were included.
RESULTS
BC treatment was the main indication for NSM, observed in 85(73.9%) young versus 33(82.5%) elderly patients, followed by risk-reducing surgery in 30(26.1%) young versus 7(17.5%) elderly patients. Complication rates did not differ between the age groups. At a median follow-up of 43 months, the overall recurrence rate was higher in the younger cohort (p = 0.04). However, when stratified into local, locoregional, contralateral, and distant metastasis, no statistical difference was observed. During the follow-up, only 2(1.7%) young patients died.
CONCLUSION
Our findings elucidate a higher recurrence rate of breast cancer in younger patients undergoing NSM, which may correlate with the fact that age is an independent prognostic factor. High overall survival and low complication rates were evidenced in the two groups showing the safety of NSM for young and elderly patients.
目的
本研究比较了 115 例年龄<40 岁（年轻组）与 40 例年龄>60 岁（老年组）接受保乳乳房切除术（NSM）作为降低风险手术或乳腺癌（BC）治疗的患者的适应证和结局。
方法
2004 年 1 月至 2018 年 12 月期间，对接受 NSM 的年轻和老年患者进行了研究，这些患者至少有 6 个月的随访期，且数据完整。
结果
BC 治疗是 NSM 的主要适应证，在 85 例（73.9%）年轻患者和 33 例（82.5%）老年患者中观察到，其次是 30 例（26.1%）年轻患者和 7 例（17.5%）老年患者接受了降低风险手术。两组的并发症发生率无差异。在中位随访 43 个月时，年轻组的总体复发率更高（p=0.04）。然而，当按局部、局部区域、对侧和远处转移分层时，未观察到统计学差异。在随访期间，只有 2 例（1.7%）年轻患者死亡。
结论
我们的研究结果阐明了接受 NSM 的年轻患者乳腺癌复发率较高，这可能与年龄是独立预后因素的事实有关。两组均表现出高总生存率和低并发症发生率，证明了 NSM 对年轻和老年患者的安全性。
Zotero 插件