酮的机械化学二氟甲基化反应
Mechanochemical difluoromethylations of ketones.
作者信息
Ke Jinbo, van Bonn Pit, Bolm Carsten
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
出版信息
Beilstein J Org Chem. 2024 Nov 4;20:2799-2805. doi: 10.3762/bjoc.20.235. eCollection 2024.
Abstract
We present a mechanochemical synthesis of difluoromethyl enol ethers. Utilizing an in situ generation of difluorocarbenes, ketones are efficiently converted to the target products under solvent-free conditions. The reactions proceed at room temperature and are complete within 90 minutes, demonstrating both efficiency and experimental simplicity.
摘要
我们展示了一种二氟甲基烯醇醚的机械化学合成方法。利用二氟卡宾的原位生成，酮在无溶剂条件下能高效转化为目标产物。反应在室温下进行，90分钟内完成，兼具高效性和实验简便性。
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