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Fludrocortisone with hydrocortisone in sepsis: new evidence in an ongoing debate.

作者信息

Ranzani Otavio, Annane Djillali, Singer Mervyn

机构信息

ISGlobal, Barcelona, Spain.

Heart Institute, Hospital das Clinicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.

出版信息

Intensive Care Med. 2024 Dec;50(12):2138-2140. doi: 10.1007/s00134-024-07699-8. Epub 2024 Nov 12.

DOI:10.1007/s00134-024-07699-8
PMID:39531050
Abstract
摘要

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Fludrocortisone with hydrocortisone in sepsis: new evidence in an ongoing debate.脓毒症中氟氢可的松与氢化可的松联用：持续争论中的新证据
Intensive Care Med. 2024 Dec;50(12):2138-2140. doi: 10.1007/s00134-024-07699-8. Epub 2024 Nov 12.
2
Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.氟氢可的松联合氢化可的松与单独使用氢化可的松治疗脓毒性休克的疗效：随机对照试验的系统评价和网络荟萃分析。
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3
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Infection. 2025 Apr;53(2):553-560. doi: 10.1007/s15010-024-02381-z. Epub 2024 Aug 27.
4
Do We Need to Administer Fludrocortisone in Addition to Hydrocortisone in Adult Patients With Septic Shock? An Updated Systematic Review With Bayesian Network Meta-Analysis of Randomized Controlled Trials and an Observational Study With Target Trial Emulation.是否需要在脓毒性休克成人患者中除氢化可的松外还加用地氟可特？一项基于随机对照试验的贝叶斯网状荟萃分析和目标试验模拟的观察性研究的更新系统评价。
Crit Care Med. 2024 Apr 1;52(4):e193-e202. doi: 10.1097/CCM.0000000000006161. Epub 2023 Dec 29.
5
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BMJ Open. 2020 Dec 2;10(12):e040931. doi: 10.1136/bmjopen-2020-040931.

本文引用的文献

1
Is fludrocortisone the missing piece in septic shock? A closer look. Author's reply.氟氢可的松是感染性休克中缺失的关键因素吗？深入探讨。作者回复
Intensive Care Med. 2025 Jan;51(1):207-208. doi: 10.1007/s00134-024-07692-1. Epub 2024 Oct 29.
2
Effectiveness of fludrocortisone and hydrocortisone versus hydrocortisone alone in septic shock with and without pneumonia.氟氢可的松联合氢化可的松与单独使用氢化可的松治疗伴或不伴肺炎的感染性休克的疗效比较
Intensive Care Med. 2024 Sep;50(9):1535-1537. doi: 10.1007/s00134-024-07552-y. Epub 2024 Jul 22.
3
Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock.
成人脓毒性休克患者低剂量氢化可的松的患者水平荟萃分析。
NEJM Evid. 2023 Jun;2(6):EVIDoa2300034. doi: 10.1056/EVIDoa2300034. Epub 2023 May 22.
4
Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial.氢化可的松加氟氢可的松用于社区获得性肺炎相关感染性休克：APROCCHSS 3期随机试验的亚组分析
Lancet Respir Med. 2024 May;12(5):366-374. doi: 10.1016/S2213-2600(23)00430-7. Epub 2024 Feb 1.
5
Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.氟氢可的松联合氢化可的松与单独使用氢化可的松治疗脓毒性休克的疗效：随机对照试验的系统评价和网络荟萃分析。
Am J Respir Crit Care Med. 2024 May 15;209(10):1219-1228. doi: 10.1164/rccm.202310-1785OC.
6
2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia.2024聚焦更新：脓毒症、急性呼吸窘迫综合征及社区获得性肺炎中糖皮质激素使用指南
Crit Care Med. 2024 May 1;52(5):e219-e233. doi: 10.1097/CCM.0000000000006172. Epub 2024 Jan 19.
7
Do We Need to Administer Fludrocortisone in Addition to Hydrocortisone in Adult Patients With Septic Shock? An Updated Systematic Review With Bayesian Network Meta-Analysis of Randomized Controlled Trials and an Observational Study With Target Trial Emulation.是否需要在脓毒性休克成人患者中除氢化可的松外还加用地氟可特？一项基于随机对照试验的贝叶斯网状荟萃分析和目标试验模拟的观察性研究的更新系统评价。
Crit Care Med. 2024 Apr 1;52(4):e193-e202. doi: 10.1097/CCM.0000000000006161. Epub 2023 Dec 29.
8
Glucocorticoids with or without fludrocortisone in septic shock: a narrative review from a biochemical and molecular perspective.糖皮质激素联合或不联合氟氢可的松治疗脓毒性休克：从生化和分子角度的叙述性综述。
Br J Anaesth. 2024 Jan;132(1):53-65. doi: 10.1016/j.bja.2023.10.034. Epub 2023 Nov 28.
9
Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock.氟氢可的松与单独使用氢化可的松对比在脓毒性休克患者中的疗效。
JAMA Intern Med. 2023 May 1;183(5):451-459. doi: 10.1001/jamainternmed.2023.0258.
10
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.拯救脓毒症运动：2021年脓毒症和脓毒性休克国际管理指南
Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2.