Division of Social and Behavioural Health Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
PLoS One. 2024 Nov 12;19(11):e0313322. doi: 10.1371/journal.pone.0313322. eCollection 2024.
Pre-exposure prophylaxis (PrEP) stands as an effective tool in preventing HIV transmission among individuals at risk of HIV infection. However, the effectiveness of daily oral PrEP is contingent on the adherence of its users, which can pose a challenge for many individuals. Various studies have explored different interventions aimed at bolstering PrEP adherence. One recurring type of intervention revolves around digital communication (e.g., SMS, mobile applications) to send reminders for PrEP usage. The objective of our systematic review and meta-analysis is to address the following research question: What is the effectiveness of digital communication interventions in enhancing daily oral PrEP adherence among individuals at a heightened risk of HIV infection? This paper presents our study protocol.
We will conduct searches across four health-related databases: Embase, PubMed, Web of Science, and PsycINFO. We will also explore other sources, including clinical trials registries and grey literature. Our search will be restricted to original randomized controlled trials published in English, French, and Spanish conducted since 2012, when PrEP was approved, to today. To ensure rigor, three reviewers will perform the systematic review and meta-analysis. This systematic review will adhere to the guidelines outlined in the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our primary outcome of interest is proper daily oral PrEP adherence, which we will measure using association metrics (e.g., odds ratios).
This review will offer insights into the effectiveness of utilizing digital communication methods to assist individuals at risk of HIV in improving their PrEP adherence.
International Prospective Register for Systematic Reviews (PROSPERO) number CRD42023471269.
暴露前预防（PrEP）是预防 HIV 感染高危人群感染 HIV 的有效手段。然而，每日口服 PrEP 的有效性取决于其使用者的依从性，这对许多人来说是一个挑战。许多研究探索了不同的干预措施来提高 PrEP 的依从性。一种反复出现的干预措施是围绕数字通信（例如，短信、移动应用程序）来发送 PrEP 使用提醒。我们的系统评价和荟萃分析的目的是回答以下研究问题：数字通信干预措施在提高 HIV 感染高危个体每日口服 PrEP 依从性方面的有效性如何？本文介绍了我们的研究方案。
我们将在四个健康相关数据库（Embase、PubMed、Web of Science 和 PsycINFO）中进行搜索。我们还将探索其他来源，包括临床试验注册处和灰色文献。我们的搜索将限于自 2012 年 PrEP 获得批准以来，以英文、法文和西班牙文发表的、针对 HIV 感染风险增加的个体的原创随机对照试验。为了确保严谨性，将由三名评审员进行系统评价和荟萃分析。本系统评价将遵循 2020 年系统评价和荟萃分析的首选报告项目（PRISMA）中的指南。我们感兴趣的主要结局是适当的每日口服 PrEP 依从性，我们将使用关联指标（如比值比）来衡量。
本综述将提供关于利用数字通信方法帮助 HIV 高危个体提高 PrEP 依从性的有效性的见解。
国际前瞻性系统评价登记处（PROSPERO）编号 CRD42023471269。
