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子痫前期和胎儿生长受限病例中的肝酶升高

Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction.

作者信息

Dacaj Ramadan, Izetbegovic Sebija, Stojkanovic Goran, Dreshaj Skender

机构信息

Department of Obstetrics and Gynecology, Regional Hospital, Pec, Republic of Kosova.

Private Gynecological Surgery, Sarajevo, Bosnia and Herzegovina.

出版信息

Med Arch. 2016 Feb;70(1):44-7. doi: 10.5455/medarh.2016.70.44-47. Epub 2016 Jan 31.

DOI:10.5455/medarh.2016.70.44-47
PMID:26980931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4779350/
Abstract

AIM

The aim of this study was to evaluate biochemical parameters in serum of women with preeclampsia and IUGR.

MATERIAL AND METHODS

A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group included pregnant women with preeclampsia and IUGR (n=60). Outcome measures were following values of biochemical parameters in serum of mother and fetuses: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), bilirubin (indirect and direct) and cholesterol. A blood for analysis was drawn from the cubital vein of mothers and the umbilical vein of the fetuses during delivery period.

RESULTS

The mean of maternal age was 30.0±6.1 years in women with preeclampsia and IUGR and 28.1±5.1 years in healthy pregnant women, p > 0.05. The most of women with preeclampsia and IUGR had grade III of placental maturation (48.3%). There is a significant association between the placental maturation and the diagnosis, p < 0.001. There was a statistically significant difference in body mass of newborns between IUGR and non IUGR groups, p < 0.001. There was a significant statistically difference in serum value of AST, ALT, LDH and total cholesterol between women with preeclampsia and IUGR and healthy pregnant women (all p < 0.001).

CONCLUSION

Measurement of AST, ALT, LDH, and total cholesterol in serum of pregnant women and newborns with IUGR allows the differentiation and threatening risk of perinatal complications due to hypoxia.

摘要

目的

本研究旨在评估子痫前期合并胎儿生长受限（IUGR）女性血清中的生化参数。

材料与方法

进行了一项临床前瞻性研究，纳入120名孕妇，分为两组：非IUGR组包括健康孕妇（n = 60），IUGR组包括子痫前期合并IUGR的孕妇（n = 60）。观察指标为母亲和胎儿血清中以下生化参数值：天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、乳酸脱氢酶（LDH）、胆红素（间接和直接胆红素）以及胆固醇。在分娩期从母亲的肘静脉和胎儿的脐静脉采集血样进行分析。

结果

子痫前期合并IUGR女性的平均年龄为30.0±6.1岁，健康孕妇的平均年龄为28.1±5.1岁，p>0.05。大多数子痫前期合并IUGR的女性胎盘成熟度为III级（48.3%）。胎盘成熟度与诊断之间存在显著关联，p<0.001。IUGR组与非IUGR组新生儿体重存在统计学显著差异，p<0.001。子痫前期合并IUGR的女性与健康孕妇血清中AST、ALT、LDH和总胆固醇值存在显著统计学差异（均p<0.001）。

结论

检测IUGR孕妇和新生儿血清中的AST、ALT、LDH和总胆固醇有助于鉴别因缺氧导致的围产期并发症及其风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5f/4779350/065a51c0ba1a/MA-70-44-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5f/4779350/636897fba3a1/MA-70-44-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5f/4779350/065a51c0ba1a/MA-70-44-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5f/4779350/636897fba3a1/MA-70-44-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5f/4779350/065a51c0ba1a/MA-70-44-g004.jpg

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