Rascher W, Rauh W, Brandeis W E, Huber K H, Schärer K
Acta Paediatr Scand. 1986 Jan;75(1):111-7. doi: 10.1111/j.1651-2227.1986.tb10166.x.
Plasma concentration of arginine-vasopressin (AVP) was measured in 145 healthy subjects aged one day to 18 years of age. AVP decreased with age immediately after birth. Above one year of age values of children did not significantly differ from those in adults. AVP significantly correlated with plasma and urine osmolality after water deprivation during 16 h. Plasma AVP rose during exercise and fell after volume expansion. Nausea and vomiting are potent nonosmotic determinants of AVP release in children. Nonosmotic factors of AVP release should be controlled when sampling blood for measuring AVP in children for diagnostic and investigational purposes.
在145名年龄从1天到18岁的健康受试者中测量了精氨酸加压素（AVP）的血浆浓度。出生后AVP浓度随年龄立即下降。一岁以上儿童的值与成人的值无显著差异。在16小时禁水后，AVP与血浆和尿渗透压显著相关。运动期间血浆AVP升高，容量扩张后下降。恶心和呕吐是儿童AVP释放的重要非渗透性决定因素。为诊断和研究目的在儿童中采集血液测量AVP时，应控制AVP释放的非渗透性因素。
