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介绍序贯部分主动脉阻断技术在冠状动脉旁路移植术中近端吻合及心肌保护中的优势。

Introducing sequential partial aortic clamp technique for proximal anastomoses and its advantages in myocardial protection in coronary artery bypass grafting.

机构信息

Department of Cardiac Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Sci Rep. 2024 Nov 12;14(1):27659. doi: 10.1038/s41598-024-79496-8.

Abstract

Ischemic heart disease (IHD) is a common and potentially lethal cardiovascular disorder. Coronary artery bypass grafting (CABG) is a standard procedure for treating IHD. This study aims to introduce a novel technique for proximal anastomoses in CABG. This clinical trial studied 29 cases and 29 matched controls. Data were gathered from June 2014 to June 2023. Regarding proximal anastomoses, the sequential partial aortic clamp was performed in cases, and the partial aortic clamp was done for controls. In the sequential partial aortic clamp technique, a relatively small or medium vascular clamp was used instead of one clamp for all proximal anastomoses, which closed a small amount of the aortic wall at each stage. At each stage, only one hole in the aortic wall and only one anastomosis between the conduit and the aorta was performed. After the end of each anastomosis, the clamp was opened and placed on another part of the aorta, and the next anastomosis was performed. CK-MB (p < 0.001, Eta Squared = 0.255) level was significantly lower in cases that underwent sequential partial ascending aorta clamping. However, cTnI level was not statistically different among cases and controls(p = 0.05). Of all patients, 3 (10.3%) cases and 12 (41.4%) controls developed with postoperative atrial fibrillation (p = 0.007). The sequential partial aortic clamp technique leads to less myocardial injury than the partial aortic clamp technique. Also, patients undergoing sequential partial aortic clamp technique are less likely to develop postoperative atrial fibrillation.

摘要

缺血性心脏病(IHD)是一种常见且潜在致命的心血管疾病。冠状动脉旁路移植术(CABG)是治疗 IHD 的标准程序。本研究旨在介绍 CABG 中近端吻合的一种新方法。这项临床试验研究了 29 例病例和 29 例匹配对照。数据收集于 2014 年 6 月至 2023 年 6 月。在近端吻合方面,病例组采用序贯部分主动脉夹闭,对照组采用部分主动脉夹闭。在序贯部分主动脉夹闭技术中,使用相对较小或中等的血管夹代替所有近端吻合的一个夹闭器,每个阶段仅夹闭主动脉壁的一小部分。在每个阶段,仅在主动脉壁上打一个孔,仅在导管和主动脉之间进行一个吻合。每次吻合完成后,夹闭器打开并放置在主动脉的另一部分,然后进行下一次吻合。CK-MB(p<0.001,Eta Squared=0.255)水平在接受序贯部分升主动脉夹闭的病例中显著降低。然而,cTnI 水平在病例和对照组之间没有统计学差异(p=0.05)。在所有患者中,3 例(10.3%)病例和 12 例(41.4%)对照组发生术后心房颤动(p=0.007)。序贯部分主动脉夹闭技术比部分主动脉夹闭技术导致的心肌损伤更小。此外,接受序贯部分主动脉夹闭技术的患者发生术后心房颤动的可能性更小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/11557586/e9570408f958/41598_2024_79496_Fig1_HTML.jpg

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