久坐少动：身体活动对西班牙人群死亡率的影响。
Sitting less and moving more: the impact of physical activity on mortality in the population of Spain.
机构信息
Department of Educational Sciences, University of Alcalá (UAH), Madrid, Spain.
National Centre for Epidemiology, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
出版信息
BMC Public Health. 2024 Nov 12;24(1):3140. doi: 10.1186/s12889-024-20600-y.
BACKGROUND
Sitting time (ST) constitutes a significant aspect of sedentary behavior, and its worldwide escalation raises concerns regarding public health. International guidelines recommend limiting sedentary time and replacing it with physical activity (PA) to reduce the risk of diseases and mortality. This study examines the impact of replacing ST with PA on all-cause, cardiovascular disease (CVD), and cancer mortality in a representative cohort of the population of Spain.
METHODS
We included 30 955 participants aged 15-69 years from two National Health Surveys performed in 2011 and 2017. Data were linked to mortality records as of December 2022. Data on ST, light PA (LPA), and moderate-vigorous PA (MVPA) were collected as part of the International Physical Activity Questionnaire at baseline. Isotemporal substitution analysis from Poisson regression models was used to estimate the relative risk ratio (RR) of replacing ST with LPA or MVPA.
RESULTS
During a median follow-up of 5.7 years, 957 deaths were reported. The replacement of 1 h per week of ST with 1 h per week of MVPA was significantly associated with a lower risk of all-cause (3.3%), CVD (6.7%), and cancer mortality (3.1%). Similarly, replacing 1 h per week of ST with 1 h per week of LPA was significantly associated with a lower risk of all-cause (1.6%) and cancer mortality (2.1%). Finally, substituting 1 h per week of LPA with 1 h per week of MVPA was significantly associated with a 7.6% lower risk of CVD mortality.
CONCLUSIONS
Substituting one hour per week of ST with an equivalent amount of PA was associated with a lower risk of all-cause, CVD, and cancer mortality.
背景
久坐时间（ST）是久坐行为的重要组成部分，其在全球范围内的不断增加引起了人们对公共健康的关注。国际指南建议限制久坐时间，并以体力活动（PA）替代，以降低疾病和死亡率风险。本研究在西班牙代表性人群队列中，研究了用 PA 替代 ST 对全因、心血管疾病（CVD）和癌症死亡率的影响。
方法
我们纳入了 2011 年和 2017 年两次全国健康调查中年龄在 15-69 岁的 30955 名参与者。数据与截至 2022 年 12 月的死亡率记录相关联。ST、低强度体力活动（LPA）和中高强度体力活动（MVPA）的数据是作为基线国际体力活动问卷的一部分收集的。使用泊松回归模型的等时替代分析来估计用 LPA 或 MVPA 替代 ST 每小时每周的相对风险比（RR）。
结果
在中位随访 5.7 年期间，报告了 957 例死亡。每周用 1 小时 MVPA 替代 1 小时 ST，与全因（3.3%）、CVD（6.7%）和癌症死亡率（3.1%）风险降低显著相关。同样，每周用 1 小时 ST 替代 1 小时 LPA，也与全因（1.6%）和癌症死亡率（2.1%）风险降低显著相关。最后，每周用 1 小时 LPA 替代 1 小时 MVPA，与 CVD 死亡率降低 7.6%显著相关。
结论
每周用 1 小时 ST 替代 1 小时 PA，与全因、CVD 和癌症死亡率降低相关。
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