载藤黄酸的 FeO 纳米颗粒通过 RORB/EMILIN1 轴抑制结直肠癌转移。

FeO nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis.

机构信息

Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.

Department of Thyroid and Breast Oncological Surgery, Xuzhou Medical College Affiliated Huaian Hospital, Huaian, China.

出版信息

Cell Adh Migr. 2024 Dec;18(1):38-53. doi: 10.1080/19336918.2024.2427585. Epub 2024 Nov 13.

DOI:10.1080/19336918.2024.2427585

PMID:39533963

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11562916/

Abstract

This research aims to study the effect of magnetic nanoparticles of Fe3O4 (MNP Fe3O4) containing gambogic acid (GA-MNP Fe3O4) on colorectal cancer (CRC). MNP Fe3O4 enhanced the antitumor effect of GA by inhibiting the malignant behavior of CRC cells. RORB was a target of GA, and GA activated RORB expression to inhibit metastasis of CRC. Knockdown of RORB impaired the effect of GA-MNP Fe3O4 on CRC metastasis. EMILIN1 was a target of RORB, and RORB promoted transcription of EMILIN1. Overexpression of EMILIN1 reversed the effect of knockdown of RORB on GA-MNP Fe3O4 and inhibited metastasis in CRC. These findings revealed that MNP Fe3O4 enhanced the antitumor effect of GA and activated RORB to promote EMILIN1 transcription and inhibit CRC metastasis.

摘要

本研究旨在研究载有藤黄酸的四氧化三铁磁性纳米颗粒（GA-MNP Fe3O4）对结直肠癌（CRC）的影响。MNP Fe3O4 通过抑制 CRC 细胞的恶性行为增强了 GA 的抗肿瘤作用。RORB 是 GA 的一个靶点，GA 通过激活 RORB 表达来抑制 CRC 的转移。敲低 RORB 会损害 GA-MNP Fe3O4 对 CRC 转移的作用。EMILIN1 是 RORB 的一个靶点，RORB 促进了 EMILIN1 的转录。过表达 EMILIN1 逆转了敲低 RORB 对 GA-MNP Fe3O4 的作用，并抑制了 CRC 中的转移。这些发现表明，MNP Fe3O4 增强了 GA 的抗肿瘤作用，并激活了 RORB 以促进 EMILIN1 转录并抑制 CRC 转移。