Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan Province, China.
Department of Physics, The University of Texas, Arlington, TX, 76019, USA.
Signal Transduct Target Ther. 2022 Mar 4;7(1):70. doi: 10.1038/s41392-022-00922-2.
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.
结直肠癌（CRC）是发病率最高的恶性肿瘤之一，发病率高，此外，CRC 患者可能发生肝转移，这是主要的死亡原因。尽管在诊断和治疗技术方面取得了重大进展，但结直肠肝转移（CRLM）患者的生存率仍然很低。CRLM 作为一个涉及多个因素和过程的复杂级联反应过程，具有复杂多样的分子机制。在这篇综述中，我们总结了 CRLM 的机制/病理生理学、诊断和治疗。我们还重点介绍了对 CRLM 分子基础的最新认识进展，特别强调肿瘤微环境和 CRLM 新型靶向治疗的前景，进一步改善 CRLM 患者的预后。
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